Literature summary for 1.11.1.8 extracted from

Belforte, F.S.; Targovnik, A.M.; Gonzalez-Lebrero, R.M.; Osorio Larroche, C.; Citterio, C.E.; Gonzalez-Sarmiento, R.; Miranda, M.V.; Targovnik, H.M.; Rivolta, C.M.
Kinetic characterization of human thyroperoxidase. Normal and pathological enzyme expression in Baculovirus system a molecular model of functional expression (2015), Mol. Cell. Endocrinol., 404, 9-15 .

Search for more literature for 1.11.1.8

Cloned(Commentary)

Cloned (Comment)	Organism
expression in baculovirus system	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
C808R	natural missense mutation, mutant shows higher Km values and lower reaction efficiencies thna wild-type	Homo sapiens
G387R	natural missense mutation, mutant shows higher Km values and lower reaction efficiencies thna wild-type	Homo sapiens
P499L	natural missense mutation, mutant shows higher Km values and lower reaction efficiencies thna wild-type	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
5.55	-	guaiacol	wild-type, pH 7.4, temperature not specified in the publication	Homo sapiens
7.03	-	guaiacol	mutant G387R, pH 7.4, temperature not specified in the publication	Homo sapiens
7.39	-	guaiacol	mutant P499L, pH 7.4, temperature not specified in the publication	Homo sapiens
9.67	-	guaiacol	mutant C808R, pH 7.4, temperature not specified in the publication	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P07202	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
2.42	-	mutant G387R, pH 7.4, temperature not specified in the publication	Homo sapiens
3.06	-	mutant C808R, pH 7.4, temperature not specified in the publication	Homo sapiens
4.6	-	mutant P499L, pH 7.4, temperature not specified in the publication	Homo sapiens
7.22	-	wild-type, pH 7.4, temperature not specified in the publication	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
guaiacol + H2O2	-	Homo sapiens	3,3'-dimethoxy-4,4'-biphenoquinone + H2O	-	?

Subunits

Subunits	Comment	Organism
?	x * 106000, SDS-PAGE, recombinant protein	Homo sapiens

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Release 2023.1 (January 2023)