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Literature summary for 1.11.1.8 extracted from
- Inhibition of thyroid peroxidase by dietary flavonoids (1996), Chem. Res. Toxicol., 9, 16-23.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| fisetin | - |
Sus scrofa |  |
| kaempferol | - |
Sus scrofa | |
| morin | - |
Sus scrofa | |
| myricetin | non competitive with I- | Sus scrofa | |
| naringenin | non competitive with I-, competitive with H2O2 | Sus scrofa | |
| quercetin | - |
Sus scrofa | |
| rutin | - |
Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.034 | - |
H2O2 | - |
Sus scrofa | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| iodide + H2O2 | Sus scrofa | - |
iodine + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
pig, female | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| biochanin A + H2O2 + I- | - |
Sus scrofa | 6,8-diiodobiochanin A + H2O | - |
? | |
| guaiacol + H2O2 + I- | - |
Sus scrofa | tetraguaiacol + H2O | - |
? | |
| iodide + H2O2 | - |
Sus scrofa | iodine + H2O | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.001 | - |
myricetin | - |
Sus scrofa | |
| 0.006 | - |
kaempferol | - |
Sus scrofa | |
| 0.007 | - |
quercetin | - |
Sus scrofa | |
| 0.007 | - |
naringenin | - |
Sus scrofa | |
| 0.013 | - |
morin | - |
Sus scrofa | |
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