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Literature summary for 1.11.1.6 extracted from
- Engineering of a novel tri-functional enzyme with MnSOD, catalase and cell-permeable activities (2016), Int. J. Biol. Macromol., 85, 451-459 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | design and production of a bifunctional protein with mitochondrial superoxide dismutase and catalase activities plus cell penetrating peptide from HIV-1 Tat to enable cellular internalization. Coexpression of catalase-superoxide dismutase and superoxide dismutase -Tat fusion genes allows simultaneous self-assembly of the protein sequences. The protein complex is expected to contain one tetrameric structure of catalase, four tetrameric structures of superoxide dismutase and twelve units of Tat. The complex shows cellular internalization and superior protection against paraquat-induced cell death | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P04040 | - |
- |
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Release 2023.1 (January 2023)
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