Literature summary for 1.11.1.28 extracted from

Su, T.; Si, M.; Zhao, Y.; Yao, S.; Che, C.; Liu, Y.; Chen, C.
Function of alkyl hydroperoxidase AhpD in resistance to oxidative stress in Corynebacterium glutamicum (2019), J. Gen. Appl. Microbiol., 65, 72-79 .

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Organism

Organism	UniProt	Comment	Textmining
Corynebacterium glutamicum	Q8NMX8	-	-
Corynebacterium glutamicum	Q8NN44	-	-
Corynebacterium glutamicum ATCC 13032	Q8NMX8	-	-
Corynebacterium glutamicum ATCC 13032	Q8NN44	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	AhpD contributes to regenerate a variety of thiol-dependent peroxidase in the decomposition of peroxide by linking a dihydrolipoamide dehydrogenase (Lpd)/dihydrolipoamide succinyltransferase (SucB)/NADH system through the cyclization of their own active site dithiol to the oxidized disulphide. The CXXC motif of AhpD is essential to maintain the peroxides reduction activity of thiol-dependent peroxidase. The AhpD system is an important redox system in cells besides the thioredoxin system. Corynebacterium glutamicum AhpD not only has the ability to reduce a variety of thioredoxin-dependent antioxidant enzymes, including mycothiol peroxidase, peroxiredoxin, and Ohr (organic Hydroperoxide Resistance), but also shows a higher affinity for Ohr than those of mycothiol peroxidase and peroxiredoxin, which is different from the only AhpC-reducing Mycobacterium tuberculosis AhpD	Corynebacterium glutamicum	?	-	-
additional information	AhpD contributes to regenerate a variety of thiol-dependent peroxidase in the decomposition of peroxide by linking a dihydrolipoamide dehydrogenase (Lpd)/dihydrolipoamide succinyltransferase (SucB)/NADH system through the cyclization of their own active site dithiol to the oxidized disulphide. The CXXC motif of AhpD is essential to maintain the peroxides reduction activity of thiol-dependent peroxidase. The AhpD system is an important redox system in cells besides the thioredoxin system. Corynebacterium glutamicum AhpD not only has the ability to reduce a variety of thioredoxin-dependent antioxidant enzymes, including mycothiol peroxidase, peroxiredoxin, and Ohr (organic Hydroperoxide Resistance), but also shows a higher affinity for Ohr than those of mycothiol peroxidase and peroxiredoxin, which is different from the only AhpC-reducing Mycobacterium tuberculosis AhpD	Corynebacterium glutamicum ATCC 13032	?	-	-

Synonyms

Synonyms	Comment	Organism
ahpD1	-	Corynebacterium glutamicum
ahpD2	-	Corynebacterium glutamicum

Expression

Organism	Comment	Expression
Corynebacterium glutamicum	induced under various stresses	up

General Information

General Information	Comment	Organism
malfunction	DELTAahpD1DELTAahpD2 mutants exhibit significantly decreased resistance to adverse stress conditions and increased accumulation of reactive oxygen species (ROS)	Corynebacterium glutamicum
physiological function	AhpD acts as a backup of thioredoxin to provide reducing power for peroxidase	Corynebacterium glutamicum

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Release 2023.1 (January 2023)