Literature summary for 1.11.1.24 extracted from

Nusai, K.; Doungdee, P.; Rungrotmongkol, T.
Study of drug likeness of praziquantel derivatives for the inhibition of thioredoxin peroxidase and aspartic protease in Opisthorchis viverrini by molecular docking method (2017), Curr. Appl. Sci. Technol., 17, 87-102 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
praziquantel	Opisthorchis viverrini infection predisposes the infected for cholangiocarcinoma, a cancer of the gall bladder and its ducts. Praziquantel is the drug most commonly used to cure the Opisthorchis viverrini. In the case of drug resistance of Opisthorchis viverrini, this causes the decreased cure efficiency of praziquantel. Therefore, the invention of a new drug used to supplement or substitute praziquantel especially in the case of drug resistance of Opisthorchis viverrini is very necessary. Study of drug likeness of praziquantel derivatives for the inhibition of thioredoxin peroxidase in Opisthorchis viverrini by molecular docking method. The derivative, most suitable for development as a drug for inhibiting thioredoxin peroxidase, is the derivative substituted with -CH2CH2OCH3 in R3 position	Opisthorchis viverrini

Organism

Organism	UniProt	Comment	Textmining
Opisthorchis viverrini	B4Y9T5	-	-

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Release 2023.1 (January 2023)