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Literature summary for 1.11.1.24 extracted from
- Comparative study of two thioredoxin peroxidases from disk abalone (Haliotis discus discus): cloning, recombinant protein purification, characterization of antioxidant activities and expression analysis (2008), Fish Shellfish Immunol., 24, 294-307.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | in the H2O2 reduction assay, AbTPx1 shows the ability to remove H2O2 without the presence of dithiothreitol. However, removal of H2O2 is promoted with the presence of dithiothreitol | Haliotis discus discus |  |
| dithiothreitol | in the H2O2 reduction assay, AbTPx2 shows the ability to remove H2O2 without the presence of dithiothreitol. However, removal of H2O2 is promoted with the presence of dithiothreitol | Haliotis discus discus | |
| additional information | AbTPx1 gene expression is induced by oxidative stress | Haliotis discus discus | |
| additional information | AbTPx2 gene expressions is induced by oxidative stress | Haliotis discus discus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21 (DE3) cells | Haliotis discus discus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 64500 | - |
recombinant protein, SDS-PAGE | Haliotis discus discus |
| 70500 | - |
recombinant protein, SDS-PAGE | Haliotis discus discus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Haliotis discus discus | B1N693 | disk abalone | - |
| Haliotis discus discus | B1N694 | disk abalone | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| amylose resin column chromatography | Haliotis discus discus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| abductor | - |
Haliotis discus discus | - |
| abductor muscle | - |
Haliotis discus discus | - |
| alimentary canal | - |
Haliotis discus discus | - |
| gill | - |
Haliotis discus discus | - |
| mantle | - |
Haliotis discus discus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| H2O2 + reduced thioredoxin | - |
Haliotis discus discus | H2O + oxidized thioredoxin | - |
? | |
| tert-butyl hydroperoxide + reduced thioredoxin | - |
Haliotis discus discus | tert-butanol + oxidized thioredoxin + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AbTPx1 | isozyme | Haliotis discus discus |
| AbTPx2 | isozyme | Haliotis discus discus |
| peroxiredoxin | - |
Haliotis discus discus |
| Prx | - |
Haliotis discus discus |
| thioredoxin peroxidase | - |
Haliotis discus discus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Haliotis discus discus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | 90 | H2O2 reduction activity increases from 30 to 37°C and gradually decreases from 37 to 90°C | Haliotis discus discus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Haliotis discus discus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4 | 10 | - |
Haliotis discus discus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| thioredoxin | - |
Haliotis discus discus | |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Haliotis discus discus | calculated from amino acid sequence | - |
5.7 |
| Haliotis discus discus | calculated from amino acid sequence | - |
6 |
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