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Literature summary for 1.11.1.24 extracted from

  • Kang, S.W.; Chae, H.Z.; Seo, M.S.; Kim, K.; Baines, I.C.; Rhee, S.G.
    Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha (1998), J. Biol. Chem., 273, 6297-6302.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression of Prx I, Prx II and Prx III in Escherichia coli Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol Prx I and Prx II Homo sapiens 5829
-
mitochondrion Prx III Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens together with glutathione peroxidase and catalase, Prx enzymes likely play an important role in eliminating peroxides generated during metabolism. In addition Prx I and II might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentration of H2O2 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2O2 + reduced thioredoxin
-
 Homo sapiens H2O + oxidized thioredoxin
-
 ?
additional information together with glutathione peroxidase and catalase, Prx enzymes likely play an important role in eliminating peroxides generated during metabolism. In addition Prx I and II might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentration of H2O2 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Prx I
-
 Homo sapiens
Prx II
-
 Homo sapiens
Prx III
-
 Homo sapiens