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Literature summary for 1.11.1.21 extracted from

  • Heym, B.; Alzari, P.M.; Honore, N.; Cole, S.T.
    Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis (1995), Mol. Microbiol., 15, 235-245.
    View publication on PubMed
Search for more literature for 1.11.1.21

Application

Application Comment Organism
medicine the toxicity of the anti-tuberculosis drug isoniazid is mediated by catalase-peroxidase Mycobacterium tuberculosis

Protein Variants

Protein Variants Comment Organism
L587M the mutant has wild type-like strong catalase and peroxidase activities Mycobacterium tuberculosis
R463L the mutant has wild type-like strong catalase and peroxidase activities Mycobacterium tuberculosis
S315T the mutant has weak catalase and barely detectable peroxidase activities Mycobacterium tuberculosis
T275P the mutant has very low catalase activity Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis H37Rv
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O2
-
 Mycobacterium tuberculosis oxidized 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O
-
 ?
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O2
-
 Mycobacterium tuberculosis H37Rv oxidized 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O
-
 ?
H2O2
-
 Mycobacterium tuberculosis O2 + H2O
-
 ?
H2O2
-
 Mycobacterium tuberculosis H37Rv O2 + H2O
-
 ?
o-dianisidine + H2O2
-
 Mycobacterium tuberculosis oxidized o-dianisidine + H2O
-
 ?
o-dianisidine + H2O2
-
 Mycobacterium tuberculosis H37Rv oxidized o-dianisidine + H2O
-
 ?

Synonyms

Synonyms Comment Organism
KatG
-
 Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
heme
-
 Mycobacterium tuberculosis