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Literature summary for 1.11.1.20 extracted from

  • Bertrand, J.A.; Woodward, D.F.; Sherwood, J.M.; Spenlehauer, A.; Silvestri, C.; Piscitelli, F.; Marzo, V.D.; Yamazaki, M.; Sakimura, K.; Inoue, Y.; Watanabe, K.; Overby, D.R.
    Deletion of the gene encoding prostamide/prostaglandin F synthase reveals an important role in regulating intraocular pressure (2021), Prostaglandins Leukot. Essent. Fatty Acids, 165, 102235 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prostaglandin H2 + reduced thioredoxin Mus musculus
-
 prostaglandin F2alpha + oxidized thioredoxin
-
 ?
prostamide H2 + reduced thioredoxin Mus musculus
-
 prostamide F2alpha + oxidized thioredoxin
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
eye
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prostaglandin H2 + reduced thioredoxin
-
 Mus musculus prostaglandin F2alpha + oxidized thioredoxin
-
 ?
prostamide H2 + reduced thioredoxin
-
 Mus musculus prostamide F2alpha + oxidized thioredoxin
-
 ?

Synonyms

Synonyms Comment Organism
PM/PGFS
-
 Mus musculus
prostamide/prostaglandin F synthase
-
 Mus musculus

General Information

General Information Comment Organism
malfunction the elevation of intraocular pressure caused by deletion of the enzyme gene likely results from a diversion of the endoperoxide precursor pathway to provide increased levels of those prostanoids known to raise intraocular pressure, namely prostaglandin D2 and thromboxane A2 Mus musculus
physiological function the enzyme serves an important regulatory role in the eye by providing prostaglandin F2alpha and prostamide F2alpha to constrain the influence of those prostanoids that raise intraocular pressure Mus musculus