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Literature summary for 1.11.1.13 extracted from

  • Wariishi, H.; Dunford, H.B.; MacDonald, I.D.; Gold, M.H.
    Manganese peroxidase from the lignin-degrading basidiomycete Phanerochaete chrysosporium. Transient state kinetics and reaction mechanism (1989), J. Biol. Chem., 264, 3335-3340.
    View publication on PubMed
Search for more literature for 1.11.1.13

Activating Compound

Activating Compound Comment Organism Structure
alpha-hydroxy acid stimulates by chelating Mn3+ and stabilizing its high redox potential Phanerodontia chrysosporium
citrate stimulates by chelating Mn3+ and stabilizing its high redox potential Phanerodontia chrysosporium
H2O2 H2O2-dependent Phanerodontia chrysosporium
Lactate stimulates by complexing with and stabilizing Mn3+ Phanerodontia chrysosporium
succinate activates, stabilizes Mn3+ less effective than citrate or lactate Phanerodontia chrysosporium

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Phanerodontia chrysosporium
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
46000
-
-
 Phanerodontia chrysosporium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Mn2+ + H+ + H2O2 Phanerodontia chrysosporium important component of lignin degradation system Mn3+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Phanerodontia chrysosporium
-
 white rot basidomycete
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Phanerodontia chrysosporium

Purification (Commentary)

Purification (Comment) Organism
-
 Phanerodontia chrysosporium

Reaction

Reaction Comment Organism Reaction ID
2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O kinetic mechanism Phanerodontia chrysosporium
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Mn2+ + H+ + H2O2 Mn2+ is an obligatory substrate for MnP compound II, whereas compound I formation occurs with Mn2+, p-cresol and organic peroxides, e.g. peracetic acid, m-chloroperoxybenzoic acid and p-nitroperoxybenzoic acid Phanerodontia chrysosporium Mn3+ + H2O alpha-hydroxy acids, e.g. lactate, facilitate the dissociation of Mn3+ from enzyme ?
Mn2+ + H+ + H2O2 Mn2+ is an obligatory substrate for MnP compound II, whereas compound I formation occurs with Mn2+, p-cresol and organic peroxides, e.g. peracetic acid, m-chloroperoxybenzoic acid and p-nitroperoxybenzoic acid Phanerodontia chrysosporium Mn3+ + H2O Mn3+ oxidizes phenolic lignin model compounds ?
Mn2+ + H+ + H2O2 Mn2+ is an obligatory substrate for MnP compound II, whereas compound I formation occurs with Mn2+, p-cresol and organic peroxides, e.g. peracetic acid, m-chloroperoxybenzoic acid and p-nitroperoxybenzoic acid Phanerodontia chrysosporium Mn3+ + H2O Mn3+ acts as obligatory redox coupler, oxidizing various phenols, dyes and amines ?
Mn2+ + H+ + H2O2 Mn2+ is an obligatory substrate for MnP compound II, whereas compound I formation occurs with Mn2+, p-cresol and organic peroxides, e.g. peracetic acid, m-chloroperoxybenzoic acid and p-nitroperoxybenzoic acid Phanerodontia chrysosporium Mn3+ + H2O Mn3+ oxidizes p-cresol ?
Mn2+ + H+ + H2O2 Mn2+ is an obligatory substrate for MnP compound II, whereas compound I formation occurs with Mn2+, p-cresol and organic peroxides, e.g. peracetic acid, m-chloroperoxybenzoic acid and p-nitroperoxybenzoic acid Phanerodontia chrysosporium Mn3+ + H2O Mn3+ oxidizes amines ?
Mn2+ + H+ + H2O2 Mn2+ is an obligatory substrate for MnP compound II, whereas compound I formation occurs with Mn2+, p-cresol and organic peroxides, e.g. peracetic acid, m-chloroperoxybenzoic acid and p-nitroperoxybenzoic acid Phanerodontia chrysosporium Mn3+ + H2O Mn3+ oxidizes a variety of phenols ?
Mn2+ + H+ + H2O2 Mn2+ is an obligatory substrate for MnP compound II, whereas compound I formation occurs with Mn2+, p-cresol and organic peroxides, e.g. peracetic acid, m-chloroperoxybenzoic acid and p-nitroperoxybenzoic acid Phanerodontia chrysosporium Mn3+ + H2O chelation of Mn3+ by organic acids stabilizes Mn3+ at a high redox potential ?
Mn2+ + H+ + H2O2 important component of lignin degradation system Phanerodontia chrysosporium Mn3+ + H2O
-
 ?
additional information catalytic cycle of enzyme, oxidation states: native enzyme via compound I via compound II to native enzyme, Mn2+ and phenols reduce MnP compound I to compound II, but only Mn2+ is a substrate for MnP compound II, Mn(II)/Mn(III) redox couple enables enzyme to rapidly oxidize terminal phenolic substrates Phanerodontia chrysosporium ?
-
 ?
additional information primary reaction product of peroxidation with H2O2 is enzyme compound I, formation of compound II from I follows second-order kinetic Phanerodontia chrysosporium ?
-
 ?
additional information enzyme oxidizes phenol red Phanerodontia chrysosporium ?
-
 ?
additional information in presence of Mn2+ enzyme oxidizes various organic compounds Phanerodontia chrysosporium ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.5
-
-
 Phanerodontia chrysosporium

pH Range

pH Minimum pH Maximum Comment Organism
3.1 8.3 in presence of H2O2 the formation of enzyme compound I is independent of pH over the range Phanerodontia chrysosporium

Cofactor

Cofactor Comment Organism Structure
heme one iron protoporphyrin IX prosthetic group per enzyme molecule Phanerodontia chrysosporium