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Literature summary for 1.11.1.12 extracted from
- Reversal of mitochondrial proteomic loss in Type 1 diabetic heart with overexpression of phospholipid hydroperoxide glutathione peroxidase (2013), Am. J. Physiol. Regul. Integr. Comp. Physiol., 304, R553-R565.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | MPHGPx transgenic mice made diabetic by multiple low-dose streptozotocin injections show decreased ejection fraction and fractional shortening in diabetic hearts that is reversed with hydroperoxide glutathione peroxidase mPHDPx4 overexpression. MPHGPx overexpression increases electron transport chain function while attenuating hydrogen peroxide production and lipid peroxidation in diabetic mPHGPx interfibrillar mitochondria. mPHGPx overexpression lessens proteomic loss observed in diabetic interfibrillar mitochondria. Posttranslational modifications, including oxidations and deamidations, are attenuated with mPHGPx overexpression. Mitochondrial protein import dysfunction in diabetic interfibrillar mitochondria is reversed with mPHGPx overexpression correlating with protein import constituent preservation. Oxidative phosphorylation, tricarboxylic acid cycle, and fatty acid oxidation processes most influenced in diabetic interfibrillar mitochondria are preserved by mPHGPx overexpression | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
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Release 2023.1 (January 2023)
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