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Literature summary for 1.11.1.12 extracted from

  • Puglisi, R.; Bevilacqua, A.; Carlomagno, G.; Lenzi, A.; Gandini, L.; Stefanini, M.; Mangia, F.; Boitani, C.
    Mice overexpressing the mitochondrial phospholipid hydroperoxide glutathione peroxidase in male germ cells show abnormal spermatogenesis and reduced fertility (2007), Endocrinology, 148, 4302-4309.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
production of a transgenic mouse line overexpressing mPHGPx in the testis during the prophase of the first meiotic division, when the endogenous mPHGPx level is markedly lower than in the postmeiotic phase. Such mPHGPx overexpression is associated with male germ apoptosis, seminiferous tubule disorganization and reduced fertility Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Mus musculus O70325
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Source Tissue

Source Tissue Comment Organism Textmining
spermatocyte PHGPx expression is tightly regulated in pachytene spermatocytes, with any spatial-temporal increase in PHGPx expression resulting in damage to spermatogenesis and eventual loss of haploid cells Mus musculus
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