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Literature summary for 1.11.1.12 extracted from
- Biochemical characterization of a trypanosome enzyme with glutathione-dependent peroxidase activity (2000), Biochem. J., 352, 755-761.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| His-tagged protein termed TcGPX1, expression in Escherichia coli | Trypanosoma cruzi |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00058 | - |
linoleic acid hydroperoxide | recombinant enzyme | Trypanosoma cruzi |  |
| 0.00074 | - |
L-alpha-phosphatidylcholine hydroperoxide | recombinant enzyme | Trypanosoma cruzi | |
| 0.0017 | - |
cumene hydroperoxide | recombinant enzyme | Trypanosoma cruzi | |
| 0.0056 | - |
tert-butyl hydroperoxide | recombinant enzyme | Trypanosoma cruzi | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma cruzi | - |
American trypanosome | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant enzyme from Escherichia coli | Trypanosoma cruzi |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + cumene hydroperoxide | - |
Trypanosoma cruzi | ? | - |
? | |
| glutathione + H2O2 | - |
Trypanosoma cruzi | ? | - |
? | |
| glutathione + L-alpha-phosphatidylcholine hydroperoxide | - |
Trypanosoma cruzi | ? | - |
? | |
| glutathione + linoleic acid hydroperoxide | - |
Trypanosoma cruzi | ? | - |
? | |
| glutathione + lipid hydroperoxide | - |
Trypanosoma cruzi | glutathione disulfide + lipid + H2O | - |
? | |
| glutathione + tert-butyl hydroperoxide | - |
Trypanosoma cruzi | ? | - |
? | |
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