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Literature summary for 1.10.5.1 extracted from

  • Den Braver-Sewradj, S.; Den Braver, M.; Toorneman, R.; Van Leeuwen, S.; Zhang, Y.; Dekker, S.; Vermeulen, N.; Commandeur, J.; Vos, J.
    Reduction and scavenging of chemically reactive drug metabolites by NAD(P)H quinone oxidoreductase 1 and NRH quinone oxidoreductase 2 and variability in hepatic concentrations (2018), Chem. Res. Toxicol., 31, 116-126 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.10.5.1

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
resveratrol
-
 Homo sapiens
tacrine
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P16083
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver hepatic NQO2 concentrations ranges from 2 to 31 microM Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,6-dichloroindophenol + dihydronicotinamide riboside
-
 Homo sapiens ? + nicotinamide riboside
-
 ?
2H-dibenzo[b,f]azepin-2-one + dihydronicotinamide riboside
-
 Homo sapiens ? + nicotinamide riboside
-
 ?
amodiaquine quinone imine + dihydronicotinamide riboside
-
 Homo sapiens ? + nicotinamide riboside
-
 ?
desethylamodiaquine quinone imine + dihydronicotinamide riboside
-
 Homo sapiens ? + nicotinamide riboside
-
 ?
diclofenac-1',4'-quinone imine + dihydronicotinamide riboside
-
 Homo sapiens ? + nicotinamide riboside
-
 ?
diclofenac-2,5-quinone imine + dihydronicotinamide riboside
-
 Homo sapiens ? + nicotinamide riboside
-
 ?
mefenamic acid-1',4'-quinone imine + dihydronicotinamide riboside
-
 Homo sapiens ? + nicotinamide riboside
-
 ?
mefenamic acid-2,5-quinone imine + dihydronicotinamide riboside
-
 Homo sapiens ? + nicotinamide riboside
-
 ?
additional information no substrate: 5-hydroxydiclofenac quinone imine Homo sapiens ?
-
-
N-acetyl-p-benzoquinone imine + dihydronicotinamide riboside
-
 Homo sapiens ? + nicotinamide riboside
-
 ?

Synonyms

Synonyms Comment Organism
NQO2
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.003
-
 tacrine substrate 2,6-dichloroindophenol, pH 7.4, 24°C Homo sapiens
0.028
-
 resveratrol substrate 2,6-dichloroindophenol, pH 7.4, 24°C Homo sapiens

General Information

General Information Comment Organism
physiological function NQO2 catalyzes the reduction of quinone-like metabolites derived from acetaminophen, clozapine, 4'-hydroxydiclofenac, mefenamic acid, amodiaquine, and carbamazepine. NQO2 may be a genetic risk factor for clozapine-induced agranulocytosis Homo sapiens