BRENDA - Enzyme Database
show all sequences of 1.10.5.1

The ontogeny and population variability of human hepatic dihydronicotinamide ribosidequinone oxidoreductase (NQO2)

Riches, Z.; Liu, Y.; Berman, J.M.; Walia, G.; Collier, A.C.; J. Biochem. Mol. Toxicol. 31, 0000 (2017)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
resveratrol
-
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Homo sapiens
5829
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone
Homo sapiens
-
1-(beta-D-ribofuranosyl)nicotinamide + a quinol
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
P16083
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone
-
742815
Homo sapiens
1-(beta-D-ribofuranosyl)nicotinamide + a quinol
-
-
-
?
2,6-dichloroindophenol + dihydronicotinamide riboside
-
742815
Homo sapiens
?
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 25000, SDS-PAGE
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
resveratrol
-
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Homo sapiens
5829
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone
Homo sapiens
-
1-(beta-D-ribofuranosyl)nicotinamide + a quinol
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone
-
742815
Homo sapiens
1-(beta-D-ribofuranosyl)nicotinamide + a quinol
-
-
-
?
2,6-dichloroindophenol + dihydronicotinamide riboside
-
742815
Homo sapiens
?
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 25000, SDS-PAGE
Homo sapiens
Other publictions for EC 1.10.5.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
742815
Riches
The ontogeny and population v ...
Homo sapiens
J. Biochem. Mol. Toxicol.
31
0000
2017
-
-
-
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1
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1
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1
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2
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2
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2
1
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2
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2
1
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724559
John
Design, synthesis, biological ...
Homo sapiens
Bioorg. Med. Chem.
21
6022-6037
2013
-
-
1
1
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-
34
1
-
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1
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1
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2
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1
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1
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1
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1
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1
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34
1
1
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1
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-
2
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
725512
Leung
Chloroquine binding reveals fl ...
Homo sapiens
J. Biol. Chem.
288
11242-11251
2013
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1
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2
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2
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1
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1
1
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2
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-
-
-
-
-
-
-
-
-
1
1
-
-
-
725158
Antoine
-
Characterization of cofactors, ...
Homo sapiens
Int. J. Mass Spectrom.
312
87-96
2012
-
-
1
-
-
-
4
-
1
-
-
1
-
1
-
-
-
-
-
1
-
-
2
1
1
-
-
-
1
-
-
1
-
-
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-
-
1
1
-
-
-
-
4
-
-
1
-
-
1
-
-
-
-
-
1
-
-
2
1
1
-
-
-
1
-
-
-
-
2
2
-
-
-
725669
Michaelis
Dabigatran and dabigatran ethy ...
Homo sapiens
J. Med. Chem.
55
3934-3944
2012
-
-
-
-
-
-
17
-
-
-
-
2
-
1
-
-
-
-
-
2
-
-
2
-
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-
-
-
-
-
-
1
3
-
2
-
-
-
1
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-
-
2
17
3
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-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
724751
Dufour
Mechanism-based inhibition of ...
Homo sapiens
ChemBioChem
12
1203-1208
2011
-
-
-
-
-
-
12
-
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1
-
2
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1
1
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1
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-
1
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-
12
-
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1
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-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
725071
Reybier
Insights into the redox cycle ...
Homo sapiens
Free Radic. Res.
45
1184-1195
2011
-
-
1
-
-
-
4
-
1
-
-
3
-
3
-
-
1
-
-
-
-
-
6
1
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
4
-
-
1
-
-
3
-
-
-
1
-
-
-
-
6
1
1
-
-
-
1
-
-
-
-
1
1
-
-
-
711408
Nolan
Imidazoacridin-6-ones as novel ...
Homo sapiens
Bioorg. Med. Chem. Lett.
20
2832-2836
2010
-
-
-
-
-
-
34
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34
-
-
-
-
-
-
-
34
34
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
711432
Nolan
In silico identification and b ...
Homo sapiens
Bioorg. Med. Chem. Lett.
20
7331-7336
2010
-
-
-
-
-
-
44
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
37
-
-
-
1
-
-
-
37
44
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
711470
Nolan
Triazoloacridin-6-ones as nove ...
Homo sapiens
Bioorg. Med. Chem.
18
696-706
2010
-
-
-
-
-
-
15
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
15
-
-
-
1
-
-
-
15
15
-
-
1
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-
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-
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-
1
-
-
1
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
711729
Ferry
Old and new inhibitors of quin ...
Homo sapiens
Chem. Biol. Interact.
186
103-109
2010
-
-
1
-
-
-
6
10
1
-
-
-
-
1
-
-
1
-
-
-
-
-
11
-
-
-
-
-
-
-
-
1
-
-
19
-
-
1
1
-
-
-
19
6
-
10
1
-
-
-
-
-
-
1
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
712829
Benoit
Loss of quinone reductase 2 fu ...
Rattus norvegicus
J. Neurosci.
30
12690-12700
2010
-
1
1
-
-
-
2
-
1
-
-
-
-
6
-
-
1
-
-
3
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
-
-
-
-
2
-
-
1
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-
-
-
-
-
1
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
697007
Winger
The structure of the leukemia ...
Homo sapiens
BMC Struct. Biol.
9
7
2009
-
-
1
1
-
-
1
-
-
-
-
-
-
2
-
-
-
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-
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-
-
1
-
1
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-
1
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-
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1
-
1
-
-
-
1
-
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-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
698051
Gaikwad
Evidence for NQO2-mediated red ...
Homo sapiens
Free Radic. Biol. Med.
46
253-262
2009
-
1
-
-
-
-
2
2
-
-
-
1
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
2
-
2
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699456
Maiti
Synthesis of casimiroin and op ...
Homo sapiens
J. Med. Chem.
52
1873-1884
2009
-
-
-
1
-
-
19
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
18
-
-
-
-
1
-
-
18
19
-
-
-
-
-
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
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-
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688130
Wang
Association of NRH:quinone oxi ...
Homo sapiens
J. Gerontol. A Biol. Sci. Med. Sci.
63
127-134
2008
-
-
-
-
-
-
-
-
-
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1
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2
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1
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1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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695860
Boutin
Studies of the melatonin bindi ...
Homo sapiens
Arch. Biochem. Biophys.
477
12-19
2008
-
-
1
-
10
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
3
-
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
10
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
696093
Calamini
Kinetic, thermodynamic and X-r ...
Homo sapiens
Biochem. J.
413
81-91
2008
-
-
1
1
-
-
5
-
1
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
2
-
5
-
-
1
-
1
-
-
5
5
2
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
697413
Cai
Negative regulation of quinone ...
Oryctolagus cuniculus
Clin. Exp. Pharmacol. Physiol.
35
1419-1425
2008
-
-
-
-
-
-
-
-
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1
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1
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1
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1
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1
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1
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1
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698793
Fu
Quinone reductase 2 is a catec ...
Rattus norvegicus
J. Biol. Chem.
283
23829-23835
2008
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1
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1
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1
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2
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1
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1
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-
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686136
Jamieson
NAD(P)H:quinone oxidoreductase ...
Homo sapiens
Clin. Cancer Res.
13
1584-1590
2007
-
1
-
-
-
-
-
-
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4
-
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1
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1
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1
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-
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-
-
-
-
-
-
-
-
-
-
-
671921
Celli
NRH:quinone oxidoreductase 2 ( ...
Mus musculus
Biochem. Pharmacol.
72
366-376
2006
-
-
1
-
-
-
3
-
1
-
-
-
-
6
-
-
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-
-
-
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-
5
-
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-
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-
2
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-
1
2
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
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-
-
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673791
Wang
Nulear factor Nrf2 and antioxi ...
Homo sapiens
Free Radic. Biol. Med.
40
1119-1130
2006
-
-
1
-
-
-
2
-
1
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2
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1
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1
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2
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1
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1
-
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-
-
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-
-
-
-
-
-
-
-
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674664
Iskander
NQO1 and NQO2 regulation of hu ...
Mus musculus
J. Biol. Chem.
281
30917-30924
2006
-
-
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-
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-
-
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2
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2
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