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Literature summary for 1.10.5.1 extracted from

  • Antoine, M.; Marcheteau, E.; Delagrange, P.; Ferry, G.; Boutin, J.
    Characterization of cofactors, substrates and inhibitor binding to flavoenzyme quinone reductase 2 by automated supramolecular nano-electrospray ionization mass spectrometry (2012), Int. J. Mass Spectrom., 312, 87-96.
No PubMed abstract available
Search for more literature for 1.10.5.1

Cloned(Commentary)

Cloned (Comment) Organism
expression of recombinant QR2 in Spodoptera frugiperda Sf9 cells using the baculovirus transfection method Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Melatonin
-
 Homo sapiens
additional information inhibitor binding structures, overview Homo sapiens
resveratrol
-
 Homo sapiens
S26695
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone Homo sapiens
-
 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information QR2 is overexpressed in neurodegenerative diseases Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone
-
 Homo sapiens 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone
-
 ?
additional information quinone reductase 2 (QR2) is implicated in the reduction of quinone in the presence of natural derivatives of NADH such as N-ribosyldihydronicotinamide. QR2 does not recognize NADH or NADPH as co-substrates, unlike quinone reductase 1 (QR1) Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
homodimer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
quinone reductase 2
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD flavoenzyme, binding structure, overview. 2 molecules per enzyme dimer, quantification, overview Homo sapiens

General Information

General Information Comment Organism
malfunction specific inhibitors of QR2, tested in vivo, show outstanding properties impairing memory loss Homo sapiens
additional information QR2 does not share many features with QR1. Particularly, it does not seem to have a similar detoxifying function in cells. QR2 is overexpressed in neurodegenerative diseases Homo sapiens