Application | Comment | Organism |
---|---|---|
medicine | QR2 inhibitors possibly represent a therapeutic strategy toward the treatment of learning deficits especially observed in the aged brain | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expressed in Sf9 insect cells | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
S26695 | selective inhibitor of QR2 | Rattus norvegicus | |
S29434 | selective inhibitor of QR2 | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain cortex | - |
Rattus norvegicus | - |
embryonic hippocampal cell line | - |
Rattus norvegicus | - |
hippocampus | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-benzyldihydronicotinamide + menadione | - |
Rattus norvegicus | N-benzylnicotamide + menadiol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
QR2 | - |
Rattus norvegicus |
quinone reductase 2 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | adult QR2 knock-out mice demonstrate enhanced learning abilities in various tasks, including Morris water maze, object recognition, and rotarod performance test, while other behaviors related to anxiety (elevated plus maze), depression (forced swim), and schizophrenia (prepulse inhibition) are not affected in QR2-deficient mice. QR2 inhibition protects hippocampal cells against menadione-induced toxicity and serum deprivation and can reverse cognitive deficits | Rattus norvegicus |
physiological function | QR2 plays a role in cognitive behaviors | Rattus norvegicus |