Application | Comment | Organism |
---|---|---|
medicine | estrogen quinones, including estradiol estradiol-3,4-quinone, generated by estrogen metabolism, are thought to be responsible for estrogen-initiated carcinogenesis. NQO2 could be a novel target for prevention of breast cancer initiation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | melatonin has no effect | Homo sapiens | |
quercetin | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000033 | - |
estradiol-3,4-quinone | - |
Homo sapiens | |
0.00075 | - |
17beta-17-hydroxyestr-1(10)-ene-3,4-dione | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | NQO2 catalyzes the reduction of electrophilic estrogen quinones and thereby may act as a detoxification enzyme | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
recombinant | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-benzyl-1,4-dihydronicotinamide + estradiol-3,4-quinone | - |
Homo sapiens | 1-benzyl-3-carbamoylpyridinium + estrone-3,4-quinone | - |
r | |
17beta-17-hydroxyestr-1(10)-ene-3,4-dione + N-benzyldihydronicotinamide | ping-pong mechanism, NQO2 is faster in reducing estrogen quinones than its homologue NQO1 | Homo sapiens | 17beta-estra-1(10),2,4-triene-3,4,17-triol + N-benzylnicotinamide | - |
? | |
estrone-3,4-quinone + N-benzyldihydronicotinamide | ping-pong mechanism, NQO2 is faster in reducing estrogen quinones than its homologue NQO1 | Homo sapiens | estrone-3,4-quinol + N-benzylnicotinamide | - |
? | |
additional information | NQO2 catalyzes the reduction of electrophilic estrogen quinones and thereby may act as a detoxification enzyme | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MT3/NQO2 | - |
Homo sapiens |
NQO2 | - |
Homo sapiens |
NRH:quinone oxidoreductase 2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens |