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Literature summary for 1.10.3.6 extracted from
- Characterization of soluble rifamycin oxidase from Curvularia lunata var. aeria (1993), Lett. Appl. Microbiol., 17, 1-3.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | rifamycin S is used for the production of the antibiotic rifampicin for treatment of leprosy and tuberculosis | Curvularia lunata |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ag+ | 60% inhibition at 20 mM | Curvularia lunata |  |
| Co2+ | slight inhibition | Curvularia lunata | |
| Cu2+ | slight inhibition | Curvularia lunata | |
| Fe2+ | 90% inhibition at 20 mM | Curvularia lunata | |
| Hg2+ | complete inhibition at 20 mM | Curvularia lunata | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.67 | 0.81 | Rifamycin B | - |
Curvularia lunata | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Curvularia lunata | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not affected by other metal ions than Fe2+, Hg2+, Ag+, Cu2+, Co2+ or EDTA | Curvularia lunata |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| rifamycin B + O2 | Curvularia lunata | - |
rifamycin O + H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Curvularia lunata | - |
var. aeria | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partially, gel filtration | Curvularia lunata |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| rifamycin B + O2 | - |
Curvularia lunata | rifamycin O + H2O2 | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | - |
- |
Curvularia lunata |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
half life of 9 days, after 7 days nearly 100% of activity is retained | Curvularia lunata |
| 40 | - |
half life of 100 min, activity directly declined | Curvularia lunata |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
- |
Curvularia lunata |
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