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Literature summary for 1.10.3.11 extracted from

  • Barsottini, M.; Copsey, A.; Young, L.; Baroni, R.; Cordeiro, A.; Pereira, G.; Moore, A.
    Biochemical characterization and inhibition of the alternative oxidase enzyme from the fungal phytopathogen Moniliophthora perniciosa (2020), Commun. Biol., 3, 263 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.10.3.11

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Moniliophthora perniciosa

Inhibitors

Inhibitors Comment Organism Structure
colletochlorin B mixed-type inhibitor Moniliophthora perniciosa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0685
-
 ubiquinol-1 pH 7.4, temperature not specified in the publication Moniliophthora perniciosa
0.96
-
 ubiquinol-10 pH 7.4, temperature not specified in the publication Moniliophthora perniciosa

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane membrane-bound enzyme Moniliophthora perniciosa 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 ubiquinol + O2 Moniliophthora perniciosa
-
 2 ubiquinone + 2 H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Moniliophthora perniciosa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Moniliophthora perniciosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ubiquinol + O2
-
 Moniliophthora perniciosa 2 ubiquinone + 2 H2O
-
 ?
2 ubiquinol-1 + O2
-
 Moniliophthora perniciosa 2 ubiquinone-1 + 2 H2O
-
 ?
2 ubiquinol-10 + O2
-
 Moniliophthora perniciosa 2 ubiquinone-10 + 2 H2O
-
 ?

Synonyms

Synonyms Comment Organism
alternative oxidase
-
 Moniliophthora perniciosa
MpAOX
-
 Moniliophthora perniciosa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000593
-
 pH 7.4, temperature not specified in the publication Moniliophthora perniciosa colletochlorin B

General Information

General Information Comment Organism
drug target the development of AOX-targeting antifungal agents against Moniliophthora perniciosa is an important outcome for the chocolate industry Moniliophthora perniciosa
physiological function the enzyme (MpAOX) is crucial for survival the fungal pathogen Moniliophthora perniciosa (causal agent of the witches' broom disease of cocoa) Moniliophthora perniciosa