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Literature summary for 1.10.3.11 extracted from

  • Shiba, T.; Inaoka, D.; Takahashi, G.; Tsuge, C.; Kido, Y.; Young, L.; Ueda, S.; Balogun, E.; Nara, T.; Honma, T.; Tanaka, A.; Inoue, M.; Saimoto, H.; Harada, S.; Moore, A.; Kita, K.
    Insights into the ubiquinol/dioxygen binding and proton relay pathways of the alternative oxidase (2019), Biochim. Biophys. Acta Bioenerg., 1860, 375-382 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ascofuranone quasi-irreversible inhibitor Trypanosoma brucei brucei
ferulenol competitive inhibitor, binding is completely reversible Trypanosoma brucei brucei

Metals/Ions

Metals/Ions Comment Organism Structure
Iron diiron enzyme Trypanosoma brucei brucei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 ubiquinol + O2 Trypanosoma brucei brucei
-
2 ubiquinone + 2 H2O
-
?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei brucei Q26710
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ubiquinol + O2
-
Trypanosoma brucei brucei 2 ubiquinone + 2 H2O
-
?
2 ubiquinol-1 + O2
-
Trypanosoma brucei brucei 2 ubiquinone-1 + 2 H2O
-
?

Synonyms

Synonyms Comment Organism
alternative oxidase
-
Trypanosoma brucei brucei
AOX
-
Trypanosoma brucei brucei

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000133
-
ferulenol pH 7.4, 25°C Trypanosoma brucei brucei

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000000288
-
pH 7.4, 25°C Trypanosoma brucei brucei ascofuranone
0.00000142
-
pH 7.4, 25°C Trypanosoma brucei brucei ferulenol