Organism | UniProt | Comment | Textmining |
---|---|---|---|
Niallia circulans | Q8G907 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine | - |
Niallia circulans | 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + L-methionine | when AdoMet and 2-deoxy-scyllo-inosamine are bound, reduction of the active site cluster in a pH dependent fashion allows for reductive cleavage of AdoMet, generating a 5'-deoxyadenosine radical,which can then abstract a hydrogen atom from the 2-deoxy-scyllo-inosamine substrate forming a 2-deoxy-scyllo-inosamine radical. The 2-deoxy-scyllo-inosamine radical has an estimated potential of -1.6 V, indicating that it could easily reduce either the auxiliary cluster or the AdoMet radical cluster itself | ? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
[4Fe-4S]-center | the potential of both the AdoMet [4Fe-4S] radical and auxiliary clusters can be measured simultaneously. The AdoMet [4Fe-4S] radical cluster exhibits a midpoint potential of -510 mV, while the auxiliary cluster exhibits a midpoint potential of -765 mV | Niallia circulans |