Literature summary for 1.1.99.21 extracted from

Liu, D.; Ke, X.; Hu, Z.C.; Zheng, Y.G.
Combinational expression of D-sorbitol dehydrogenase and pyrroloquinoline quinone increases 6-(N-hydroxyethyl)-amino-6-deoxy-?-L-sorbofuranose production by Gluconobacter oxydans through cofactor manipulation (2020), Enzyme Microb. Technol., 141, 109670 .

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Application

Application	Comment	Organism
pharmacology	miglitol (N-hydroxyethyl-1-deoxynojirimycin), a type of hypoglycemic drug works by competitively inhibiting alpha-glucosidase activity to control postprandial blood glucose, can be used in the treatment of type II diabetes mellitus. 6-(N-hydroxyethyl)-amino-6-deoxy-alpha-L-sorbofuranose, is a key intermediate for the synthesis of miglitol, is produced from N-2-hydroxyethyl glucamine (NHEG) by biotransformation with resting cells of Gluconobacter oxydans. Balanced co-expression of both the mSLDH and the PQQ synthases is effective for the industrial production of 6-(N-hydroxyethyl)-amino-6-deoxy-L-sorbofuranose	Gluconobacter oxydans

Organism

Organism	UniProt	Comment	Textmining
Gluconobacter oxydans	-	-	-

Synonyms

Synonyms	Comment	Organism
mSLDH	-	Gluconobacter oxydans

Cofactor

Cofactor	Comment	Organism	Structure
pyrroloquinoline quinone	the cofactor transfers redox equivalents to the respiratory chain during the biotransformation of NHEG to 6NSL	Gluconobacter oxydans

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Release 2023.1 (January 2023)