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Literature summary for 1.1.99.2 extracted from
- L-2-hydroxyglutarate dehydrogenase identification of a novel enzyme activity in rat and human liver. Implications for L-2-hydroxyglutaric acidemia (1993), Biochim. Biophys. Acta, 1225, 53-56 .
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.2 | - |
NAD+ | at pH 8.7 and 37°C | Homo sapiens |  |
| 0.4 | - |
NAD+ | at pH 8.7 and 37°C | Rattus norvegicus | |
| 4 | - |
L-2-hydroxyglutarate | at pH 8.7 and 37°C | Homo sapiens | |
| 13.3 | - |
L-2-hydroxyglutarate | at pH 8.7 and 37°C | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| additional information | no activity in heart, brain and skeletal muscle, cultured human skin fibroblasts and transformed lymphocyte | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0046 | - |
at pH 8.7 and 37°C | Rattus norvegicus |
| 0.021 | - |
at pH 8.7 and 37°C | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-2-hydroxyglutarate + NAD+ | - |
Homo sapiens | 2-oxoglutarate + NADH + H+ | - |
? | |
| L-2-hydroxyglutarate + NAD+ | - |
Rattus norvegicus | 2-oxoglutarate + NADH + H+ | - |
? | |
| additional information | no activity with 3-acetylpyridine adenine dinucleotide or NADP+ | Homo sapiens | ? | - |
? | |
| additional information | no activity with 3-acetylpyridine adenine dinucleotide or NADP+ | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| L-2-hydroxyglutarate dehydrogenase | - |
Homo sapiens |
| L-2-hydroxyglutarate dehydrogenase | - |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.3 | 9.3 | the enzyme is active over a wide pH range (7.3-9.3) with no clear optimum | Homo sapiens |
| 7.3 | 9.3 | the enzyme is active over a wide pH range (7.3-9.3) with no clear optimum | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Homo sapiens | |
| FAD | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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