Literature summary for 1.1.99.1 extracted from

Ameyama, M.; Shinagawa, E.; Matsushita, K.; Takimoto, K.; Nakashima, K.; Adachi, O.
Mammalian choline dehydrogenase is a quinoprotein (1985), Agric. Biol. Chem., 49, 3623-3626.

No PubMed abstract available

Search for more literature for 1.1.99.1

Activating Compound

Activating Compound	Comment	Organism	Structure
pyrroloquinoline quinone	as prosthetic group	Canis lupus familiaris

General Stability

General Stability	Organism
detergents, e.g. Brij 58, Triton X-100, cholate, deoxycholate or beta-octylglucoside stabilize	Canis lupus familiaris

Inhibitors

Inhibitors	Comment	Organism	Structure
Semicarbazide	-	Canis lupus familiaris

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
4.8	-	choline	-	Canis lupus familiaris

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Canis lupus familiaris	5739	-

Organism

Organism	UniProt	Comment	Textmining
Canis lupus familiaris	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
using 0.5% Brij 58 treatment, column chromatography on DEAE-cellulose and gel filtration on Toyopearl HW-60S	Canis lupus familiaris

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Canis lupus familiaris	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
choline + acceptor	electron acceptor: 2,6-dichlorophenolindophenol	Canis lupus familiaris	betaine aldehyde + reduced acceptor	-	?
choline + acceptor	electron acceptor: phenazine methosulfate	Canis lupus familiaris	betaine aldehyde + reduced acceptor	-	?
choline + acceptor	choline is the sole substrate	Canis lupus familiaris	betaine aldehyde + reduced acceptor	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	8	-	Canis lupus familiaris

Cofactor

Cofactor	Comment	Organism	Structure
pyrroloquinoline quinone	as prosthetic group	Canis lupus familiaris

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Release 2023.1 (January 2023)