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Literature summary for 1.1.98.6 extracted from

  • Mulliez, E.; Ollagnier, S.; Fontecave, M.; Eliasson, R.; Reichard, P.
    Formate is the hydrogen donor for the anaerobic ribonucleotide reductase from Escherichia coli (1995), Proc. Natl. Acad. Sci. USA, 92, 8759-8762.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

Metals/Ions Comment Organism Structure
iron-sulfur center in its active form, the enzyme contains an iron-sulfur center and an oxygen-sensitive glycyl radical (Gly681) Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P28903
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ribonucleoside 5'-triphosphate + formate
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Escherichia coli 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O in its active form, the enzyme contains an iron-sulfur center and an oxygen-sensitive glycyl radical (Gly681). The radical is generated in the inactive protein from S-adenosylmethionine by an auxiliary enzyme system. During catalysis, formate is stoichiometrically oxidized to CO2, and isotope from [3H]formate appears in water ?