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Literature summary for 1.1.98.6 extracted from
- A chemically competent thiosulfuranyl radical on the Escherichia coli class III ribonucleotide reductase (2014), J. Am. Chem. Soc., 136, 9001-9013.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | reaction with CTP (substrate) and ATP (allosteric effector) in the absence of formate leads to loss of the glycyl radical concomitant with stoichiometric formation of a new radical species and a trapped cytidine derivative that can break down to cytosine. Addition of formate to the new species results in recovery of 80% of the glycly radical and reduction of the cytidine derivative, proposed to be 3'-keto-deoxycytidine, to dCTP and a small amount of cytosine. The structure of the new radical is a thiosulfuranyl [RSSR2] radical, composed of a cysteine thiyl radical stabilized by an interaction with a methionine residue | Escherichia coli | ? | - |
? |  |
| ribonucleoside 5'-triphosphate + formate | - |
Escherichia coli | 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O | - |
? | |
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Release 2023.1 (January 2023)
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