Literature summary for 1.1.98.6 extracted from

Eliasson, R.; Reichard, P.; Mulliez, E.; Ollagnier, S.; Fontecave, M.; Liepinsh, E.; Otting, G.
The mechanism of the anaerobic Escherichia coli ribonucleotide reductase investigated with nuclear magnetic resonance spectroscopy (1995), Biochem. Biophys. Res. Commun., 214, 28-35.

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Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ribonucleoside 5'-triphosphate + formate	-	Escherichia coli	2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O	-	?

Synonyms

Synonyms	Comment	Organism
class III ribonucleoside-triphosphate reductase	-	Escherichia coli

General Information

General Information	Comment	Organism
physiological function	during the reduction of ribonucleotides with [3H]formate tritium appears in water and not in the product deoxyribonucleotide. In D2O, deuterium replaces the OH-group at carbon-2' with retention of configuration. Class I, II and class III enzymes catalyze identical reactions. Members of the three classes of reductases apparently use the same chemical mechanism in spite of having completely different protein structures	Escherichia coli

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Release 2023.1 (January 2023)