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Literature summary for 1.1.5.2 extracted from

  • Fender, J.E.; Bender, C.M.; Stella, N.A.; Lahr, R.M.; Kalivoda, E.J.; Shanks, R.M.
    Serratia marcescens quinoprotein glucose dehydrogenase activity mediates medium acidification and inhibition of prodigiosin production by glucose (2012), Appl. Environ. Microbiol., 78, 6225-6235.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.5.2

Cloned(Commentary)

Cloned (Comment) Organism
gene gdhS, expressionin Escherichia coli strain S17-1 Serratia marcescens

Protein Variants

Protein Variants Comment Organism
additional information complementation of the rig-10 mutant, DELTAcrp gdhS, glucose insensitivity phenotype using the wild-type Serratia marcescens gdhS gene or the Escherichia coli gcd gene expressed from a medium-copy-number plasmid Serratia marcescens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose + ubiquinone Serratia marcescens
-
 D-glucono-1,5-lactone + ubiquinol
-
 ?
D-glucose + ubiquinone Serratia marcescens CMS2526
-
 D-glucono-1,5-lactone + ubiquinol
-
 ?

Organism

Organism UniProt Comment Textmining
Serratia marcescens
-
 gene gdhS
-
Serratia marcescens CMS2526
-
 gene gdhS
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose + ubiquinone
-
 Serratia marcescens D-glucono-1,5-lactone + ubiquinol
-
 ?
D-glucose + ubiquinone
-
 Serratia marcescens CMS2526 D-glucono-1,5-lactone + ubiquinol
-
 ?

Synonyms

Synonyms Comment Organism
QGDH
-
 Serratia marcescens
quinoprotein glucose dehydrogenase
-
 Serratia marcescens

Cofactor

Cofactor Comment Organism Structure
pyrroloquinoline quinone quinoprotein, required for QGDH activity Serratia marcescens

General Information

General Information Comment Organism
physiological function multiple genetic loci involved in quinoprotein glucose dehydrogenase activity are required for glucose inhibition of prodigiosin production, including pyrroloquinoline quinone and ubiquinone biosynthetic genes. The enzymatic products of GDH activity are involved in the inhibitory effect. D-Glucono-1,5-lactone and D-gluconic acid, but not D-gluconate, are able to inhibit prodigiosin production. Oxidation of D-glucose by quinoprotein GDH initiates a reduction in pH that inhibits prodigiosin production through transcriptional control of the prodigiosin biosynthetic operon Serratia marcescens