Literature summary for 1.1.5.13 extracted from

Knorr, S.; Sinn, M.; Galetskiy, D.; Williams, R.; Wang, C.; Mueller, N.; Mayans, O.; Schleheck, D.; Hartig, J.
Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate (2018), Nat. Commun., 9, 5071 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasmic membrane	-	Escherichia coli	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-2-hydroxyglutarate + a quinone	Escherichia coli	-	2-oxoglutarate + a quinol	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-NTA column chromatography	Escherichia coli

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-2-hydroxyglutarate + a quinone	-	Escherichia coli	2-oxoglutarate + a quinol	-	?
L-2-hydroxyglutarate + menaquinone-4	-	Escherichia coli	2-oxoglutarate + menaquinol-4	-	?
L-2-hydroxyglutarate + ubiquinone-1	-	Escherichia coli	2-oxoglutarate + ubiquinol-1	-	?

Synonyms

Synonyms	Comment	Organism
L-2-hydroxyglutarate dehydrogenase	-	Escherichia coli
L2HG dehydrogenase	-	Escherichia coli
L2HG:quinone oxidoreductase	-	Escherichia coli
lhgO	-	Escherichia coli

Cofactor

Cofactor	Comment	Organism	Structure
FAD	dependent on	Escherichia coli

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Release 2023.1 (January 2023)