BRENDA - Enzyme Database
show all sequences of 1.1.5.10

Mammalian D-2-hydroxy acid dehydrogenase. Effect of inhibitors and reaction sequence

Cammack, R.; Biochem. J. 118, 405-408 (1970)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
oxalate
competitive
Oryctolagus cuniculus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Oryctolagus cuniculus
-
-
-
Purification (Commentary)
Commentary
Organism
-
Oryctolagus cuniculus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
kidney
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-lactate + 2,6-dichlorophenol-indophenol
ordered mechanism, first D-lactate and then 2,6-dichlorophenol-indophenol bind to the enzyme to form a ternary complex, from which pyruvate and reduced 2,6-dichlorophenol-indophenol dissociate in that oder
726894
Oryctolagus cuniculus
pyruvate + reduced 2,6-dichlorophenol-indophenol
-
-
-
?
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
oxalate
competitive
Oryctolagus cuniculus
Purification (Commentary) (protein specific)
Commentary
Organism
-
Oryctolagus cuniculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
kidney
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-lactate + 2,6-dichlorophenol-indophenol
ordered mechanism, first D-lactate and then 2,6-dichlorophenol-indophenol bind to the enzyme to form a ternary complex, from which pyruvate and reduced 2,6-dichlorophenol-indophenol dissociate in that oder
726894
Oryctolagus cuniculus
pyruvate + reduced 2,6-dichlorophenol-indophenol
-
-
-
?
Other publictions for EC 1.1.5.10
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
727253
Kato
Quinone-dependent D-lactate de ...
Corynebacterium glutamicum, Corynebacterium glutamicum DSM 20300
BMC Microbiol.
10
321
2010
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
726894
Cammack
Mammalian D-2-hydroxy acid deh ...
Oryctolagus cuniculus
Biochem. J.
118
405-408
1970
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
724205
Cammack
Assay, purification and proper ...
Oryctolagus cuniculus
Biochem. J.
115
55-64
1969
-
-
-
-
-
-
2
-
1
-
2
-
-
1
-
-
1
-
-
1
-
2
2
-
1
-
2
-
1
-
4
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
1
-
2
-
-
-
-
1
-
1
-
2
2
-
1
-
2
-
1
-
4
-
-
-
-
-
-
-