Literature summary for 1.1.3.15 extracted from

Mattu, S.; Fornari, F.; Quagliata, L.; Perra, A.; Angioni, M.M.; Petrelli, A.; Menegon, S.; Morandi, A.; Chiarugi, P.; Ledda-Columbano, G.M.; Gramantieri, L.; Terracciano, L.; Giordano, S.; Columbano, A.
The metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival (2016), J. Hepatol., 64, 891-898 .

Search for more literature for 1.1.3.15

Application

Application	Comment	Organism
diagnostics	the metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival. Dysregulation of HAO2 is a very early event in the development of hepatocellular carcinoma and it may represent a useful diagnostic and prognostic marker for human hepatocellular carcinoma	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
gene HAO2, quantitative RT-PCR enzyme expression analysis	Rattus norvegicus
gene HAO2, quantitative RT-PCR enzyme expression analysis	Homo sapiens
gene HAO2, quantitative RT-PCR enzyme expression analysis	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	Rattus norvegicus hepatocellular carcinoma cells are transduced by a HAO2 encoding lentiviral vector and grafted in mice	Rattus norvegicus
additional information	Rattus norvegicus hepatocellular carcinoma cells are transduced by a HAO2 encoding lentiviral vector and grafted in mice	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
peroxisome	-	Rattus norvegicus	5777	-
peroxisome	-	Homo sapiens	5777	-
peroxisome	-	Mus musculus	5777	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
an (S)-2-hydroxy carboxylate + O2	Rattus norvegicus	-	a 2-oxo carboxylate + H2O2	-	?
an (S)-2-hydroxy carboxylate + O2	Homo sapiens	-	a 2-oxo carboxylate + H2O2	-	?
an (S)-2-hydroxy carboxylate + O2	Mus musculus	-	a 2-oxo carboxylate + H2O2	-	?
an (S)-2-hydroxy carboxylate + O2	Mus musculus C3H	-	a 2-oxo carboxylate + H2O2	-	?
an (S)-2-hydroxy carboxylate + O2	Rattus norvegicus Fischer 344	-	a 2-oxo carboxylate + H2O2	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NYQ3	-	-
Mus musculus	Q9NYQ2	-	-
Mus musculus C3H	Q9NYQ2	-	-
Rattus norvegicus	Q07523	-	-
Rattus norvegicus Fischer 344	Q07523	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocellular carcinoma cell	HAO2 is downregulated	Mus musculus	-
hepatocellular carcinoma cell	Hao2 is highly significantly downregulated in 12/12 HCCs developed by the CMD protocol and in 16/16 HCCs generated by chronic DENA treatment	Rattus norvegicus	-
hepatocellular carcinoma cell	HAO2 mRNA levels are strongly downregulated in two distinct series of human HCCs, when compared to both normal and cirrhotic peritumoral liver, overview	Homo sapiens	-
liver	-	Rattus norvegicus	-
liver	-	Homo sapiens	-
liver	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
an (S)-2-hydroxy carboxylate + O2	-	Rattus norvegicus	a 2-oxo carboxylate + H2O2	-	?
an (S)-2-hydroxy carboxylate + O2	-	Homo sapiens	a 2-oxo carboxylate + H2O2	-	?
an (S)-2-hydroxy carboxylate + O2	-	Mus musculus	a 2-oxo carboxylate + H2O2	-	?
an (S)-2-hydroxy carboxylate + O2	-	Mus musculus C3H	a 2-oxo carboxylate + H2O2	-	?
an (S)-2-hydroxy carboxylate + O2	-	Rattus norvegicus Fischer 344	a 2-oxo carboxylate + H2O2	-	?

Synonyms

Synonyms	Comment	Organism
Hao2	-	Rattus norvegicus
Hao2	-	Homo sapiens
Hao2	-	Mus musculus

Cofactor

Cofactor	Comment	Organism	Structure
FMN	dependent on	Rattus norvegicus
FMN	dependent on	Homo sapiens
FMN	dependent on	Mus musculus

Expression

Organism	Comment	Expression
Rattus norvegicus	the metabolic gene HAO2 is downregulated in hepatocellular carcinoma. Hao2 downregulation is species- and etiology-independent in humans and rodents	down
Homo sapiens	the metabolic gene HAO2 is downregulated in hepatocellular carcinoma. Hao2 downregulation is species- and etiology-independent in humans and rodents	down
Mus musculus	the metabolic gene HAO2 is downregulated in hepatocellular carcinoma. Hao2 downregulation is species- and etiology-independent in humans and rodents	down

General Information

General Information	Comment	Organism
evolution	the enzyme belongs to the family of L-2-hydroxy acid oxidases	Rattus norvegicus
evolution	the enzyme belongs to the family of L-2-hydroxy acid oxidases	Homo sapiens
evolution	the enzyme belongs to the family of L-2-hydroxy acid oxidases	Mus musculus
physiological function	L-2-hydroxy acid oxidases are flavin mononucleotide-dependent peroxisomal enzymes, responsible for the oxidation of L-2-hydroxy acids to ketoacids, resulting in the formation of hydrogen peroxide. Oncosuppressive role of HAO2 in hepatocarcinogenesis	Rattus norvegicus
physiological function	L-2-hydroxy acid oxidases are flavin mononucleotide-dependent peroxisomal enzymes, responsible for the oxidation of L-2-hydroxy acids to ketoacids, resulting in the formation of hydrogen peroxide. Oncosuppressive role of HAO2 in hepatocarcinogenesis	Homo sapiens
physiological function	L-2-hydroxy acid oxidases are flavin mononucleotide-dependent peroxisomal enzymes, responsible for the oxidation of L-2-hydroxy acids to ketoacids, resulting in the formation of hydrogen peroxide. Oncosuppressive role of HAO2 in hepatocarcinogenesis	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)