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Literature summary for 1.1.3.15 extracted from

  • Streitenberger, S.A.; Lopez-Mas, J.A.; Sanchez-Ferrer, A.; Garcia-Carmona, F.
    Non-linear slow-binding inhibition of Aerococcus viridans lactate oxidase by Cibacron Blue 3GA (2001), J. Enzyme Inhib., 16, 301-312.
    View publication on PubMed

Application

Application Comment Organism
medicine enzyme is used in clinical chemistry for the determination of (S)-lactate in blood in some pathological diseases such as diabetes, heart diseases and shock syndrome Aerococcus viridans

Inhibitors

Inhibitors Comment Organism Structure
(R)-lactate at pH 7.0 Aerococcus viridans
2-Hydroxybutyrate at pH 7.0 Aerococcus viridans
Cibacron blue 3GA at a concentration higher than 0.001 mM is a normal competitive inhibitor, at concentrations below 0.001 mM the inhibition is time-, dye- and pH-dependent Aerococcus viridans
glycolate
-
Aerococcus viridans
L-Mandelate at pH 7.0 Aerococcus viridans
oxalate at pH 7.0 Aerococcus viridans

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.175
-
(S)-lactate
-
Aerococcus viridans

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
48200
-
4 * 48200, SDS-PAGE Aerococcus viridans
187300
-
gel filtration Aerococcus viridans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-lactate + O2 Aerococcus viridans no decarboxylation pyruvate + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Aerococcus viridans
-
strain ATCC 11563
-

Purification (Commentary)

Purification (Comment) Organism
-
Aerococcus viridans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-lactate + O2 no decarboxylation Aerococcus viridans pyruvate + H2O2
-
?

Subunits

Subunits Comment Organism
tetramer 4 * 48200, SDS-PAGE Aerococcus viridans

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Aerococcus viridans

Cofactor

Cofactor Comment Organism Structure
FMN
-
Aerococcus viridans

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00169
-
Cibacron blue 3GA at pH 6.0 Aerococcus viridans
0.3
-
L-Mandelate at pH 7.0 Aerococcus viridans
0.317
-
glycolate at pH 7.0 Aerococcus viridans
0.317
-
2-hydroxy butyrate at pH 7.0 Aerococcus viridans
0.5
-
oxalate at pH 7.0 Aerococcus viridans
9.04
-
(R)-lactate at pH 7.0 Aerococcus viridans