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Literature summary for 1.1.3.15 extracted from

  • Domenech, S.E.; Machado De Domenech, E.E.; Blanco, A.
    Molecular forms of L-alpha-hydroxy acid oxidase from rat kidney (1973), Biochim. Biophys. Acta, 321, 54-63.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-oxobutyrate non-competitive inhibition at 5 mM Rattus sp.
2-oxoisocaproate non-competitive inhibition at 5 mM, most active inhibitor of 2-keto acids, oxidation of 2-hydroxybutyrate most sensitive Rattus sp.
2-oxoisovalerate non-competitive inhibition at 5 mM Rattus sp.
2-oxovalerate non-competitive inhibition at 5 mM Rattus sp.
DL-2-hydroxyisocaproate marked inhibition above 50 mM Rattus sp.
DL-2-hydroxyvalerate marked inhibition above 50 mM Rattus sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.6
-
DL-2-hydroxyvalerate
-
Rattus sp.
0.6
-
DL-2-hydroxyisocaproate
-
Rattus sp.
0.6
-
DL-2-hydroxyisovalerate
-
Rattus sp.
0.8 0.9 DL-2-hydroxycaproate
-
Rattus sp.
2.4 2.8 DL-2-hydroxybutyrate
-
Rattus sp.
5.6 5.7 L-lactate
-
Rattus sp.

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus sp. 5829
-
mitochondrion preparation of heavy and light mitochondria, 2 distinct molecular forms Rattus sp. 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DL-2-hydroxybutyrate + O2 Rattus sp. higher affinity with C5 and C6 hydroxy acids 2-oxobutyrate + H2O2
-
?
DL-2-hydroxycaproate + O2 Rattus sp.
-
2-oxocaproate + H2O2
-
?
DL-2-hydroxyisocaproate + O2 Rattus sp.
-
2-oxoisocaproate + H2O2
-
?
DL-2-hydroxyisovalerate + O2 Rattus sp. low activity 2-oxoisovalerate + H2O2
-
?
DL-2-hydroxyvalerate + O2 Rattus sp.
-
2-oxovalerate + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Rattus sp.
-
-
-

Purification (Commentary)

Purification (Comment) Organism
to homogeneity, chromatography steps Rattus sp.

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Rattus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DL-2-hydroxybutyrate + O2 higher affinity with C5 and C6 hydroxy acids Rattus sp. 2-oxobutyrate + H2O2
-
?
DL-2-hydroxycaproate + O2
-
Rattus sp. 2-oxocaproate + H2O2
-
?
DL-2-hydroxyisocaproate + O2
-
Rattus sp. 2-oxoisocaproate + H2O2
-
?
DL-2-hydroxyisovalerate + O2 low activity Rattus sp. 2-oxoisovalerate + H2O2
-
?
DL-2-hydroxyvalerate + O2
-
Rattus sp. 2-oxovalerate + H2O2
-
?
L-lactate + 2,6-dichlorophenolindophenol lower activity for preparation from "heavy" mitochondria Rattus sp. pyruvate + reduced 2,6-dichlorophenolindophenol
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.6 8.9 substrate: DL-2-hydroxybutyrate Rattus sp.
8.9 9.4 substrate: DL-2-hydroxyisocaproate Rattus sp.

Cofactor

Cofactor Comment Organism Structure
FMN
-
Rattus sp.