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Literature summary for 1.1.2.10 extracted from
- Role of rare earth elements in methanol oxidation (2019), Curr. Opin. Chem. Biol., 49, 39-44 .
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0008 | - |
methanol | pH and temperature not specified in the publication, lanthanide: Eu3+, Lu3+ | Methylacidiphilum fumariolicum |  |
| 0.0008 | - |
methanol | pH and temperature not specified in the publication, lanthanide: La3+, Ce3+, Pr3+, Nd3+ | Methylacidiphilum fumariolicum | |
| 0.0009 | - |
methanol | pH and temperature not specified in the publication, lanthanide: Eu3+ | Methylacidiphilum fumariolicum | |
| 0.0013 | - |
methanol | pH and temperature not specified in the publication, lanthanide: Eu3+, La3+ | Methylacidiphilum fumariolicum | |
| 0.029 | - |
methanol | pH and temperature not specified in the publication, lanthanide: Ce3+ | Bradyrhizobium sp. | |
| 0.029 | - |
methanol | pH and temperature not specified in the publication, lanthanide: Nd3+ | Methylorubrum extorquens | |
| 0.039 | - |
methanol | pH and temperature not specified in the publication, lanthanide: Ce3+ | Methylomonas sp. LW13 | |
| 0.044 | - |
methanol | pH and temperature not specified in the publication, lanthanide: La3+ | Methylorubrum extorquens | |
| 0.055 | - |
methanol | pH and temperature not specified in the publication, lanthanide: Ce3+ | Methylotenera mobilis | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| periplasm | - |
Bradyrhizobium sp. | - |
- |
| periplasm | - |
Methylotenera mobilis | - |
- |
| periplasm | - |
Methylacidiphilum fumariolicum | - |
- |
| periplasm | - |
Methylomonas sp. LW13 | - |
- |
| periplasm | - |
Methylorubrum extorquens | - |
- |
| periplasm | - |
Methylobacterium aquaticum | - |
- |
| periplasm | - |
Methylotuvimicrobium buryatense | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ce3+ | lanthanide-dependent enzyme | Bradyrhizobium sp. | |
| Ce3+ | lanthanide-dependent enzyme | Methylotenera mobilis | |
| Ce3+ | lanthanide-dependent enzyme | Methylacidiphilum fumariolicum | |
| Ce3+ | lanthanide-dependent enzyme | Methylomonas sp. LW13 | |
| Eu3+ | lanthanide-dependent enzyme | Methylacidiphilum fumariolicum | |
| La3+ | lanthanide-dependent enzyme | Methylacidiphilum fumariolicum | |
| La3+ | lanthanide-dependent enzyme | Methylorubrum extorquens | |
| Lu3+ | lanthanide-dependent enzyme | Methylacidiphilum fumariolicum | |
| Nd3+ | lanthanide-dependent enzyme | Methylacidiphilum fumariolicum | |
| Nd3+ | lanthanide-dependent enzyme | Methylorubrum extorquens | |
| Pr3+ | lanthanide-dependent enzyme | Methylacidiphilum fumariolicum | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bradyrhizobium sp. | - |
- |
- |
| Methylacidiphilum fumariolicum | - |
- |
- |
| Methylacidiphilum fumariolicum SolV | - |
- |
- |
| Methylobacterium aquaticum | A0A0C6F7V8 | - |
- |
| Methylobacterium aquaticum 22A | A0A0C6F7V8 | - |
- |
| Methylomonas sp. LW13 | - |
- |
- |
| Methylorubrum extorquens | C5B120 | - |
- |
| Methylotenera mobilis | - |
- |
- |
| Methylotenera mobilis JLW8 | - |
- |
- |
| Methylotuvimicrobium buryatense | A0A3F2YLY8 | - |
- |
| Methylotuvimicrobium buryatense 5G | A0A3F2YLY8 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| methanol + phenazine methosulfate | - |
Bradyrhizobium sp. | formaldehyde + reduced phenazine methosulfate | - |
? | |
| methanol + phenazine methosulfate | - |
Methylotenera mobilis | formaldehyde + reduced phenazine methosulfate | - |
? | |
| methanol + phenazine methosulfate | - |
Methylacidiphilum fumariolicum | formaldehyde + reduced phenazine methosulfate | - |
? | |
| methanol + phenazine methosulfate | - |
Methylomonas sp. LW13 | formaldehyde + reduced phenazine methosulfate | - |
? | |
| methanol + phenazine methosulfate | - |
Methylorubrum extorquens | formaldehyde + reduced phenazine methosulfate | - |
? | |
| methanol + phenazine methosulfate | - |
Methylobacterium aquaticum | formaldehyde + reduced phenazine methosulfate | - |
? | |
| methanol + phenazine methosulfate | - |
Methylotuvimicrobium buryatense | formaldehyde + reduced phenazine methosulfate | - |
? | |
| methanol + phenazine methosulfate | - |
Methylacidiphilum fumariolicum SolV | formaldehyde + reduced phenazine methosulfate | - |
? | |
| methanol + phenazine methosulfate | - |
Methylobacterium aquaticum 22A | formaldehyde + reduced phenazine methosulfate | - |
? | |
| methanol + phenazine methosulfate | - |
Methylotuvimicrobium buryatense 5G | formaldehyde + reduced phenazine methosulfate | - |
? | |
| methanol + phenazine methosulfate | - |
Methylotenera mobilis JLW8 | formaldehyde + reduced phenazine methosulfate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | - |
Bradyrhizobium sp. |
| homodimer | - |
Methylotenera mobilis |
| homodimer | - |
Methylacidiphilum fumariolicum |
| homodimer | - |
Methylomonas sp. LW13 |
| homodimer | - |
Methylorubrum extorquens |
| homodimer | - |
Methylobacterium aquaticum |
| homodimer | - |
Methylotuvimicrobium buryatense |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| XoxF | - |
Bradyrhizobium sp. |
| XoxF | - |
Methylacidiphilum fumariolicum |
| XoxF | - |
Methylotuvimicrobium buryatense |
| xoxF1 | - |
Methylorubrum extorquens |
| XoxF4-1 | - |
Methylotenera mobilis |
| XoxF4-2 | - |
Methylotenera mobilis |
| XoxF5 | - |
Methylomonas sp. LW13 |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Bradyrhizobium sp. |
| 7 | - |
- |
Methylotenera mobilis |
| 7 | - |
- |
Methylacidiphilum fumariolicum |
| 7 | - |
- |
Methylomonas sp. LW13 |
| 7 | - |
- |
Methylorubrum extorquens |
| 7 | - |
- |
Methylobacterium aquaticum |
| 7 | - |
- |
Methylotuvimicrobium buryatense |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyrroloquinoline quinone | pyrroloquinoline quinone-containing enzyme | Bradyrhizobium sp. | |
| pyrroloquinoline quinone | pyrroloquinoline quinone-containing enzyme | Methylotenera mobilis | |
| pyrroloquinoline quinone | pyrroloquinoline quinone-containing enzyme | Methylacidiphilum fumariolicum | |
| pyrroloquinoline quinone | pyrroloquinoline quinone-containing enzyme | Methylomonas sp. LW13 | |
| pyrroloquinoline quinone | pyrroloquinoline quinone-containing enzyme | Methylorubrum extorquens | |
| pyrroloquinoline quinone | pyrroloquinoline quinone-containing enzyme | Methylobacterium aquaticum | |
| pyrroloquinoline quinone | pyrroloquinoline quinone-containing enzyme | Methylotuvimicrobium buryatense | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Methylorubrum extorquens | overexpression of xoxF at higher calcium concentrations compared to lanthanides | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | xoxF is required for the expression of mxaF in Methylobacterium aquaticum 22A, since xoxF deletion mutants are not able to grow in the presence of calcium | Methylobacterium aquaticum |
| metabolism | xoxF is required for the expression of mxaF in Methylobacterium aquaticum 22A, since xoxF deletion mutants are not able to grow in the presence of calcium | Methylobacterium aquaticum |
| metabolism | XoxF is the preferred enzyme for methanol oxidation, even when calcium is present in 100fold higher concentrations than lanthanide | Methylotuvimicrobium buryatense |
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