Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.B63 extracted from

  • Wang, Y.; Li, J.; Wu, Q.; Zhu, D.
    Microbial stereospecific reduction of 3-quinuclidinone with newly isolated Nocardia sp. and Rhodococcus erythropolis (2013), J. Mol. Catal. B, 88, 14-19.
No PubMed abstract available
Search for more literature for 1.1.1.B63

Application

Application Comment Organism
synthesis the enzyme can be used for synthesis of optically pure 3-quinuclidinol. Optically pure 3-quinuclidinol is an important intermediate for the synthesis of various anticholinergic drugs. (S)-3-Quinuclidinol is a very promising chiral building blocks for synthesis of serotonin receptor antagonist drugs and anticholinergic drugs Rhodococcus erythropolis

Cloned(Commentary)

Cloned (Comment) Organism
phylogenetic tree Rhodococcus erythropolis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-quinuclidinone + NADPH + H+ Rhodococcus erythropolis stereospecific reduction of 3-quinuclidinone (S)-3-quinuclidinol + NADP+
-
 ?
3-quinuclidinone + NADPH + H+ Rhodococcus erythropolis WY1406 stereospecific reduction of 3-quinuclidinone (S)-3-quinuclidinol + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Rhodococcus erythropolis
-
-
-
Rhodococcus erythropolis WY1406
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information strain WY1406 utilizes most of the tested sugars, i.e. D-glucose, glycerol, maltose, sucrose, arabinose, sorbitol, except mannitol, for growth Rhodococcus erythropolis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-quinuclidinone + NADPH + H+ stereospecific reduction of 3-quinuclidinone Rhodococcus erythropolis (S)-3-quinuclidinol + NADP+
-
 ?
3-quinuclidinone + NADPH + H+ stereospecific reduction of 3-quinuclidinone with over 99% enantiomeric excess, effects of concentration of 3-quinuclidinone hydrochloride, overview Rhodococcus erythropolis (S)-3-quinuclidinol + NADP+
-
 ?
3-quinuclidinone + NADPH + H+ stereospecific reduction of 3-quinuclidinone Rhodococcus erythropolis WY1406 (S)-3-quinuclidinol + NADP+
-
 ?
3-quinuclidinone + NADPH + H+ stereospecific reduction of 3-quinuclidinone with over 99% enantiomeric excess, effects of concentration of 3-quinuclidinone hydrochloride, overview Rhodococcus erythropolis WY1406 (S)-3-quinuclidinol + NADP+
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
 Rhodococcus erythropolis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 8
-
 Rhodococcus erythropolis

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rhodococcus erythropolis