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Literature summary for 1.1.1.B51 extracted from
- Microbial stereospecific reduction of 3-quinuclidinone with newly isolated Nocardia sp. and Rhodococcus erythropolis (2013), J. Mol. Catal. B, 88, 14-19.
No PubMed abstract available
Application
| Application | Comment | Organism |
|---|---|---|
| synthesis | the enzyme can be used for synthesis of optically pure 3-quinuclidinol. Optically pure 3-quinuclidinol is an important intermediate for the synthesis of various anticholinergic drugs. (R)-3-Quinuclidinol is used to synthesize muscarinic M1 or M3 receptor antagonists such as talsaclidine, revatropate, and solifenacin | Nocardia sp. WY1202 |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| phylogenetic tree | Nocardia sp. WY1202 |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-quinuclidinone + NADPH + H+ | Nocardia sp. WY1202 | stereospecific reduction of 3-quinuclidinone | (R)-3-quinuclidinol + NADP+ | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Nocardia sp. WY1202 | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | apart from D-glucose and glycerol, various sugars and alcohols like maltose, sucrose, arabinose, mannitol, sorbitol are not utilized by strain WY1202 for growth | Nocardia sp. WY1202 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-quinuclidinone + NADPH + H+ | stereospecific reduction of 3-quinuclidinone | Nocardia sp. WY1202 | (R)-3-quinuclidinol + NADP+ | - |
? | |
| 3-quinuclidinone + NADPH + H+ | stereospecific reduction of 3-quinuclidinone with over 85-95% enantiomeric excess, effects of concentration of 3-quinuclidinone hydrochloride, overview | Nocardia sp. WY1202 | (R)-3-quinuclidinol + NADP+ | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
- |
Nocardia sp. WY1202 |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Nocardia sp. WY1202 |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Nocardia sp. WY1202 | |
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