Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(+)-gossypol | potent inhibitor of 11betaHSD2 | Homo sapiens | |
(+)-gossypol | potent inhibitor of 11betaHSD2 | Rattus norvegicus | |
(+/-)-gossypol | potent inhibitor of 11betaHSD2 | Homo sapiens | |
(+/-)-gossypol | potent inhibitor of 11betaHSD2 | Rattus norvegicus | |
(-)-gossypol | potent inhibitor of 11betaHSD2 | Homo sapiens | |
(-)-gossypol | potent inhibitor of 11betaHSD2 | Rattus norvegicus | |
carbenoxolone | - |
Homo sapiens | |
carbenoxolone | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
corticosterone + NAD+ | Homo sapiens | - |
11-dehydrocorticosterone + NADH + H+ | - |
? | |
corticosterone + NAD+ | Rattus norvegicus | - |
11-dehydrocorticosterone + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Homo sapiens | - |
kidney | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
corticosterone + NAD+ | - |
Homo sapiens | 11-dehydrocorticosterone + NADH + H+ | - |
? | |
corticosterone + NAD+ | - |
Rattus norvegicus | 11-dehydrocorticosterone + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-hydroxysteroid dehydrogenase type 2 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 2 | - |
Rattus norvegicus |
11betaHSD2 | - |
Homo sapiens |
11betaHSD2 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens | |
NAD+ | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00002 | - |
pH and temperature not specified in the publication | Homo sapiens | carbenoxolone | |
0.00005 | - |
pH and temperature not specified in the publication | Rattus norvegicus | carbenoxolone | |
0.00061 | - |
pH and temperature not specified in the publication | Rattus norvegicus | (+)-gossypol | |
0.00088 | - |
pH and temperature not specified in the publication | Rattus norvegicus | (+/-)-gossypol | |
0.00105 | - |
pH and temperature not specified in the publication | Homo sapiens | (+)-gossypol | |
0.00105 | - |
pH and temperature not specified in the publication | Homo sapiens | (+/-)-gossypol | |
0.00133 | - |
pH and temperature not specified in the publication | Rattus norvegicus | (-)-gossypol | |
0.0019 | - |
pH and temperature not specified in the publication | Homo sapiens | (-)-gossypol |