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Literature summary for 1.1.1.B40 extracted from

  • Chen, B.B.; Lin, H.; Hu, G.X.; Su, Y.; Zhou, H.Y.; Lian, Q.Q.; Cai, H.; Hardy, D.O.; Gu, D.Y.; Ge, R.S.
    The (+)- and (-)-gossypols potently inhibit human and rat 11beta-hydroxysteroid dehydrogenase type 2 (2009), J. Steroid Biochem. Mol. Biol., 113, 177-181.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(+)-gossypol potent inhibitor of 11betaHSD2 Homo sapiens
(+)-gossypol potent inhibitor of 11betaHSD2 Rattus norvegicus
(+/-)-gossypol potent inhibitor of 11betaHSD2 Homo sapiens
(+/-)-gossypol potent inhibitor of 11betaHSD2 Rattus norvegicus
(-)-gossypol potent inhibitor of 11betaHSD2 Homo sapiens
(-)-gossypol potent inhibitor of 11betaHSD2 Rattus norvegicus
carbenoxolone
-
Homo sapiens
carbenoxolone
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
corticosterone + NAD+ Homo sapiens
-
11-dehydrocorticosterone + NADH + H+
-
?
corticosterone + NAD+ Rattus norvegicus
-
11-dehydrocorticosterone + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Homo sapiens
-
kidney
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
corticosterone + NAD+
-
Homo sapiens 11-dehydrocorticosterone + NADH + H+
-
?
corticosterone + NAD+
-
Rattus norvegicus 11-dehydrocorticosterone + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
11beta-hydroxysteroid dehydrogenase type 2
-
Homo sapiens
11beta-hydroxysteroid dehydrogenase type 2
-
Rattus norvegicus
11betaHSD2
-
Homo sapiens
11betaHSD2
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NAD+
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00002
-
pH and temperature not specified in the publication Homo sapiens carbenoxolone
0.00005
-
pH and temperature not specified in the publication Rattus norvegicus carbenoxolone
0.00061
-
pH and temperature not specified in the publication Rattus norvegicus (+)-gossypol
0.00088
-
pH and temperature not specified in the publication Rattus norvegicus (+/-)-gossypol
0.00105
-
pH and temperature not specified in the publication Homo sapiens (+)-gossypol
0.00105
-
pH and temperature not specified in the publication Homo sapiens (+/-)-gossypol
0.00133
-
pH and temperature not specified in the publication Rattus norvegicus (-)-gossypol
0.0019
-
pH and temperature not specified in the publication Homo sapiens (-)-gossypol