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Literature summary for 1.1.1.B40 extracted from

  • Johansson, L.; Fotsch, C.; Bartberger, M.D.; Castro, V.M.; Chen, M.; Emery, M.; Gustafsson, S.; Hale, C.; Hickman, D.; Homan, E.; Jordan, S.R.; Komorowski, R.; Li, A.; McRae, K.; Moniz, G.; Matsumoto, G.; Orihuela, C.; Palm, G.; Veniant, M.; Wang, M.; Williams, M.; Zhang, J.
    2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice (2008), J. Med. Chem., 51, 2933-2943.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
the 11beta-HSD2 enzyme is produced in HEK-293 cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisol + NAD+
-
Homo sapiens cortisone + NADH
-
ir

Synonyms

Synonyms Comment Organism
11beta-HSD2
-
Homo sapiens
11beta-hydroxysteroid dehydrogenase type 2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens