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Literature summary for 1.1.1.B40 extracted from

  • Sadosky, P.W.; Scammell, J.G.
    Increased production of 11beta-hydroxysteroid dehydrogenase type 2 in the kidney microsomes of squirrel monkeys (Saimiri spp.) (2008), Comp. Med., 58, 180-187.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine squirrel monkeys protect the mineralocorticoid receptor from activation by high cortisol levels in the kidney via upregulation of 11beta-HSD2 activity through increased production of the enzyme Saimiri

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome 1beta-hydroxysteroid dehydrogenase 2 activity in suirrel monkey kidney microsomes is 3- to 7-times higher than that seen in microsomes from pig or rabbit. Enzyme protein is 4- to 9-times greater in suirrel monkey kidney microsomes than in microsomes from pig or rabbit Sus scrofa
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microsome 1beta-hydroxysteroid dehydrogenase 2 activity in suirrel monkey kidney microsomes is 3- to 7-times higher than that seen in microsomes from pig or rabbit. Enzyme protein is 4- to 9-times greater in suirrel monkey kidney microsomes than in microsomes from pig or rabbit Saimiri
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microsome 1beta-hydroxysteroid dehydrogenase 2 activity in suirrel monkey kidney microsomes is 3- to 7-times higher than that seen in microsomes from pig or rabbit. Enzyme protein is 4- to 9-times greater in suirrel monkey kidney microsomes than in microsomes from pig or rabbit Oryctolagus cuniculus
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Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus P51976 isoform 11beta-HSD2
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Saimiri
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isoform 11beta-HSD2
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Sus scrofa
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isoform 11beta-HSD2
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Source Tissue

Source Tissue Comment Organism Textmining
kidney
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Sus scrofa
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kidney
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Saimiri
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kidney
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Oryctolagus cuniculus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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the intrinsic activities of squirrel monkey and human enzyme are similar Saimiri