Cloned (Comment) | Organism |
---|---|
gene HSD11B2, DNA and amino acid sequence determination and analysis, microsatellite genotyping | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisol + NAD+ | Homo sapiens | isozyme 11beta-HSD2, inactivation of cortisol, which interacts with the mineralocorticoid receptor, isozyme 11beta-HSD2 inhibition leads to stimulation of sodium and water reabsorption and to an increase of the intravascular volume that suppresses renin and secondarily an increase of blood pressure | cortisone + NADH | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
normotensive persons and patients with low renin hypertension, LREH | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | normotensive persons and patients with low renin hypertension, LREH, expression and activity of isozyme 11beta-HSD2 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisol + NAD+ | isozyme 11beta-HSD2 | Homo sapiens | cortisone + NADH | - |
? | |
cortisol + NAD+ | isozyme 11beta-HSD2, inactivation of cortisol, which interacts with the mineralocorticoid receptor, isozyme 11beta-HSD2 inhibition leads to stimulation of sodium and water reabsorption and to an increase of the intravascular volume that suppresses renin and secondarily an increase of blood pressure | Homo sapiens | cortisone + NADH | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11 beta-hydroxysteroid dehydrogenase type 2 | - |
Homo sapiens |
11betaHSD2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |