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Literature summary for 1.1.1.B40 extracted from

  • Carvajal, C.A.; Romero, D.G.; Mosso, L.M.; Gonzalez, A.A.; Campino, C.; Montero, J.; Fardella, C.E.
    Biochemical and genetic characterization of 11 beta-hydroxysteroid dehydrogenase type 2 in low-renin essential hypertensives (2005), J. Hypertens., 23, 71-77.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene HSD11B2, DNA and amino acid sequence determination and analysis, microsatellite genotyping Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cortisol + NAD+ Homo sapiens isozyme 11beta-HSD2, inactivation of cortisol, which interacts with the mineralocorticoid receptor, isozyme 11beta-HSD2 inhibition leads to stimulation of sodium and water reabsorption and to an increase of the intravascular volume that suppresses renin and secondarily an increase of blood pressure cortisone + NADH
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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normotensive persons and patients with low renin hypertension, LREH
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Source Tissue

Source Tissue Comment Organism Textmining
additional information normotensive persons and patients with low renin hypertension, LREH, expression and activity of isozyme 11beta-HSD2 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisol + NAD+ isozyme 11beta-HSD2 Homo sapiens cortisone + NADH
-
?
cortisol + NAD+ isozyme 11beta-HSD2, inactivation of cortisol, which interacts with the mineralocorticoid receptor, isozyme 11beta-HSD2 inhibition leads to stimulation of sodium and water reabsorption and to an increase of the intravascular volume that suppresses renin and secondarily an increase of blood pressure Homo sapiens cortisone + NADH
-
?

Synonyms

Synonyms Comment Organism
11 beta-hydroxysteroid dehydrogenase type 2
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Homo sapiens
11betaHSD2
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Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens