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Literature summary for 1.1.1.B40 extracted from
- Proinflammatory cytokines inhibit human placental 11beta-hydroxysteroid dehydrogenase type 2 activity through Ca2+ and cAMP pathways (2006), Am. J. Physiol. Endocrinol. Metab., 290, E282-E288.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| A23187 | inhibits isozyme 11beta-HSD2 strongly | Homo sapiens |  |
| forskolin | slight inhibitory effect in absence of interleukin-1beta | Homo sapiens | |
| interleukin-1beta | inhibits isozyme 11beta-HSD2, forskolin acts antagonistically strongly | Homo sapiens | |
| additional information | inhibitory effects, antogonistic and agonistic effects of inhibitors and compounds, overview, no inhibition of isozyme 11beta-HSD2 by 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate | Homo sapiens | |
| Nifed | inhibits isozyme 11beta-HSD2 slightly | Homo sapiens | |
| SQ-22536 | inhibits isozyme 11beta-HSD2 | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cortisol + NAD+ | Homo sapiens | isozyme 11beta-HSD2 catalyzes the reverse reaction with cofactor NAD+ | cortisone + NADH | - |
ir | |
| additional information | Homo sapiens | proinflammatory cytokines inhibit placental isozyme 11beta-HSD2 activity through Ca2+ and cAMP pathways, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
isozyme 11beta-HSD2 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| placenta | almost exclusively isozyme 11beta-HSD2 | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cortisol + NAD+ | isozyme 11beta-HSD2 catalyzes the reverse reaction with cofactor NAD+ | Homo sapiens | cortisone + NADH | - |
ir | |
| additional information | proinflammatory cytokines inhibit placental isozyme 11beta-HSD2 activity through Ca2+ and cAMP pathways, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 11beta-HSD2 | - |
Homo sapiens |
| 11beta-hydroxysteroid dehydrogenase type 2 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | 11beta-HSD2 | Homo sapiens | |
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