KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000084 | - |
11beta,21-dihydroxypregn-4-en-3,20-dione | temperature not specified in the publication, pH 5.5-6 | Homo sapiens | |
0.00089 | - |
17,21-dihydroxy-pregn-4-ene-3,11,20-trione | i.e. cortisone, temperature not specified in the publication, pH 5.5-6 | Homo sapiens | |
0.0014 | - |
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione | i.e. cortisol, temperature not specified in the publication, pH 5.5-6 | Homo sapiens | |
0.0022 | - |
21-hydroxy-pregn-4-en-3,11,20-trione | temperature not specified in the publication, pH 5.5-6 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+ | Homo sapiens | i.e. cortisol | 17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH | i.e. cortisone | r | |
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ | Homo sapiens | i.e. corticosterone | 21-hydroxy-pregn-4-en-3,11,20-trione + NADH | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | two forms present, one NAD-specific the other NADP+-dependent | Homo sapiens | - |
Storage Stability | Organism |
---|---|
-20°C, cytosol depleted fraction, 10 mM phosphate buffer, 0.25 M sucrose, stable for 2 days | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+ | i.e. cortisol | Homo sapiens | 17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH | i.e. cortisone | r | |
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ | i.e. corticosterone | Homo sapiens | 21-hydroxy-pregn-4-en-3,11,20-trione + NADH | - |
r |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
4 | - |
- |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | 6 | oxidase activity | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 10 | 11-dehydrogenase activity, broad range of pH optimum | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Homo sapiens |