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Literature summary for 1.1.1.B40 extracted from

  • Zhang, Y.D.; Lorenzo, B.; Reidenberg, M.M.
    Inhibition of 11beta-hydroxysteroid dehydrogenase obtained from guinea pig kidney by furosemide, naringenin and some other compounds (1994), J. Steroid Biochem. Mol. Biol., 49, 81-85.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3beta-hydroxy-11-oxo-18beta-olean-12-en-30-oic-acid IC50: 0.254 mM; i.e. glycyrrhetinic acid Cavia porcellus
chenodeoxycholic acid IC50: 0.513 mM Cavia porcellus
cholic acid IC50: 3.529 mM Cavia porcellus
Ethacrynic acid IC50: 0.452 mM Cavia porcellus
Furosemide IC50: 0.059 mM, competitive Cavia porcellus
naringenin IC50: 0.336 mM Cavia porcellus
naringin IC50: 2.373 mM Cavia porcellus
Phenylbutazone IC50: 1.358 mM Cavia porcellus
sistosterol IC50: 1.395 mM Cavia porcellus
stigmasterol IC50: 1.968 mM Cavia porcellus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.008
-
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione i.e. cortisol Cavia porcellus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+ Cavia porcellus i.e. cortisol 17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH i.e. cortisone ?

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
guinea pig
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney cortex Cavia porcellus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+ i.e. cortisol Cavia porcellus 17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH i.e. cortisone ?

Synonyms

Synonyms Comment Organism
11beta-OHSD
-
Cavia porcellus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Cavia porcellus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.059
-
IC50: 0.059 mM, competitive Cavia porcellus Furosemide
0.254
-
IC50: 0.254 mM Cavia porcellus 3beta-hydroxy-11-oxo-18beta-olean-12-en-30-oic-acid
0.336
-
IC50: 0.336 mM Cavia porcellus naringenin
0.452
-
IC50: 0.452 mM Cavia porcellus Ethacrynic acid
0.513
-
IC50: 0.513 mM Cavia porcellus chenodeoxycholic acid
1.358
-
IC50: 1.358 mM Cavia porcellus Phenylbutazone
1.395
-
IC50: 1.395 mM Cavia porcellus sistosterol
1.968
-
IC50: 1.968 mM Cavia porcellus stigmasterol
2.373
-
IC50: 2.373 mM Cavia porcellus naringin
3.529
-
IC50: 3.529 mM Cavia porcellus cholic acid