Cloned (Comment) | Organism |
---|---|
expression in CHOP-C4 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3beta-hydroxy-11-oxo-18beta-olean-12-en-30-oic-acid | i.e. glycyrrhetinic acid; potent inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000051 | - |
11beta,21-dihydroxypregn-4-en-3,20-dione | - |
Homo sapiens | |
0.000047 | - |
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione | i.e. cortisol | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
44140 | - |
x * 44140, calculation from cDNA sequence | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ | Homo sapiens | i.e. corticosterone | 21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+ | - |
ir | |
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH | Homo sapiens | i.e. cortisone | 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+ | i.e. cortisol | ir | |
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH | Homo sapiens | important role in modulating mineralocorticoid and glucocorticoid receptor occupancy by glucocorticoids | 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+ | i.e. cortisol | ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | - |
Homo sapiens | - |
kidney | highly expressed | Homo sapiens | - |
ovary | - |
Homo sapiens | - |
pancreas | highly expressed | Homo sapiens | - |
placenta | highly expressed | Homo sapiens | - |
prostate gland | - |
Homo sapiens | - |
small intestine | - |
Homo sapiens | - |
spleen | low levels of mRNA | Homo sapiens | - |
testis | low levels of mRNA | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ | i.e. corticosterone | Homo sapiens | 21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+ | - |
ir | |
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH | i.e. cortisone | Homo sapiens | 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+ | i.e. cortisol | ir | |
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH | important role in modulating mineralocorticoid and glucocorticoid receptor occupancy by glucocorticoids | Homo sapiens | 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+ | i.e. cortisol | ir | |
dexamethasone + NAD+ | isoform 11beta-HSD2 | Homo sapiens | 11-dehydromethasone + NADH | - |
ir |
Subunits | Comment | Organism |
---|---|---|
? | x * 44140, calculation from cDNA sequence | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD | NAD-specific 11beta-HSD isoform type 2 | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |