Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.B40 extracted from

  • Blum , S.; Buhler, H.
    Characterization of human placental 11beta-hydroxysteroid dehydrogenase, a key enzyme of cortocosteroid metabolism (1995), Cell. Physiol. Biochem., 5, 167-175.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate IC50 in the presence of NADP+: 0.12 mM, IC50 in the presence of NAD+: 5.6 mM; i.e. CHAPS Homo sapiens
3beta-hydroxy-11-oxo-18beta-olean-12-en-30-oic-acid IC50 in the presence of NAD+: 0.000097 mM, IC50 in the presence of NADP+: 0.0003 mM; i.e. glycyrrhetinic acid Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0000044
-
NAD+ reduction of corticosterone, pH and temperature not specified in the publication Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ Homo sapiens i.e. corticosterone, clear but not exclusive preference for NAD+, only oxidative activity 21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
ir

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta constitutes an important barrier for 11-OH steroids during pregnancy between maternal and fetal organism, presence of two isoforms Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ i.e. corticosterone, clear but not exclusive preference for NAD+, only oxidative activity Homo sapiens 21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
ir

Cofactor

Cofactor Comment Organism Structure
NAD+ clear but not exclusive preference for NAD+ Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000097
-
pH and temperature not specified in the publication Homo sapiens 3beta-hydroxy-11-oxo-18beta-olean-12-en-30-oic-acid
5.6
-
pH and temperature not specified in the publication Homo sapiens 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate