Literature summary for 1.1.1.B40 extracted from

Alfaidy, N.; Blot-Chabaud, M.; Robic, D.; Kenouch, S.; Bourbouze, R.; Bonvalet, J.P.; Farman, N.
Characteristics and regulation of 11beta-hydroxysteroid dehydrogenase of proximal and distal nephron (1995), Biochim. Biophys. Acta, 1243, 461-468.

Search for more literature for 1.1.1.B40

Inhibitors

Inhibitors	Comment	Organism	Structure
aldosterone	sensitive	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1beta,21-dihydroxypregn-4-en-3,20-dione + NAD+	Rattus norvegicus	i.e. corticosterone, no reductase activity in aldosterone-sensitive collecting duct	21-hydroxy-pregn-4-en-3,11,20-trione + NADH	-	ir

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
collecting duct	aldosterone-sensitive, NAD+ specificity	Rattus norvegicus	-
kidney	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1beta,21-dihydroxypregn-4-en-3,20-dione + NAD+	i.e. corticosterone, no reductase activity in aldosterone-sensitive collecting duct	Rattus norvegicus	21-hydroxy-pregn-4-en-3,11,20-trione + NADH	-	ir

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Release 2023.1 (January 2023)