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Literature summary for 1.1.1.B3 extracted from

  • Yamamoto, H.; Matsuyama, A.; Kobayashi, Y.
    Synthesis of (R)-1,3-butanediol by enantioselective oxidation using whole recombinant Escherichia coli cells expressing (S)-specific secondary alcohol dehydrogenase (2002), Biosci. Biotechnol. Biochem., 4, 925-927.
No PubMed abstract available

Application

Application Comment Organism
synthesis synthesis of (R)-1,3-butanediol from its racemate by stereoselective oxidation of the (S)-isomer using (S)-specific secondary alcohol dehydrogenase in whole recombinant Escherichia coli cells. Yield of the (R)-product reaches 72.6 g/l, with a molar recovery yield of 48.4% and an optical purity of 95% enantiomeric excess Candida parapsilosis

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Candida parapsilosis

Organism

Organism UniProt Comment Textmining
Candida parapsilosis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-1,3-butanediol + NAD+ + H+
-
Candida parapsilosis 4-hydroxy-2-butanone + NADH enantioselective oxidation of the (S)-isomer ?

Synonyms

Synonyms Comment Organism
SADH
-
Candida parapsilosis

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Candida parapsilosis
NADH
-
Candida parapsilosis