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Literature summary for 1.1.1.95 extracted from

  • Rohde, J.M.; Brimacombe, K.R.; Liu, L.; Pacold, M.E.; Yasgar, A.; Cheff, D.M.; Lee, T.D.; Rai, G.; Baljinnyam, B.; Li, Z.; Simeonov, A.; Hall, M.D.; Shen, M.; Sabatini, D.M.; Boxer, M.B.
    Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors (2018), Bioorg. Med. Chem., 26, 1727-1739 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.95

Inhibitors

Inhibitors Comment Organism Structure
(3R)-N-(4,6-dimethylpyridin-2-yl)-3-methyl-4-[[4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbothioamide
-
 Homo sapiens
(3R,5S)-N-(4,6-dimethylpyridin-2-yl)-3,5-dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbothioamide
-
 Homo sapiens
(3S)-N-(4,6-dimethylpyridin-2-yl)-3-methyl-4-[[4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbothioamide
-
 Homo sapiens
(4-methylpyridin-2-yl)[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanethione
-
 Homo sapiens
2-(4-methylpyridin-2-yl)-1-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethane-1-thione
-
 Homo sapiens
3-phosphooxypyruvate product inhibition Homo sapiens
4-benzyl-N-(4,6-dimethylpyridin-2-yl)piperazine-1-carbothioamide
-
 Homo sapiens
4-[(2-chlorophenyl)methyl]-N-(4,6-dimethylpyridin-2-yl)piperazine-1-carbothioamide
-
 Homo sapiens
4-[(3-chlorophenyl)methyl]-N-(4,6-dimethylpyridin-2-yl)piperazine-1-carbothioamide
-
 Homo sapiens
4-[(4,6-dimethylpyridin-2-yl)carbamothioyl]-1-[[4-(trifluoromethyl)phenyl]methyl]piperazine-2-carboxylic acid
-
 Homo sapiens
4-[(4-bromophenyl)methyl]-N-(4,6-dimethylpyridin-2-yl)piperazine-1-carbothioamide
-
 Homo sapiens
4-[3-(trifluoromethyl)phenyl]-N-[4-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide
-
 Homo sapiens
methyl 2-([4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioyl]amino)pyridine-4-carboxylate
-
 Homo sapiens
N'-(4,6-dimethylpyridin-2-yl)-N-methyl-N-[2-(methyl[[4-(trifluoromethyl)phenyl]methyl]amino)ethyl]thiourea
-
 Homo sapiens
N-(3-methylphenyl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)(oxo)[4-(trifluoromethyl)phenyl]ethanethioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-3-(hydroxymethyl)-4-[[4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-3-([[4-(trifluoromethyl)phenyl]methyl]amino)piperidine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-3-methyl-4-[[4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-3-phenyl-4-[[4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-3-[3-(trifluoromethyl)anilino]piperidine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-3-[4-(trifluoromethyl)anilino]piperidine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-(2-methoxyphenyl)piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-(3-methoxyphenyl)piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-(4-methoxyphenyl)piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-(pyridin-2-yl)piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-(pyridin-3-yl)piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-(pyridin-4-yl)piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[(2-fluorophenyl)methyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[(2-methylphenyl)methyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[(3-fluorophenyl)methyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[(3-methylphenyl)methyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[(4-fluorophenyl)methyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[(4-methylphenyl)methyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[(pyridin-2-yl)methyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[(pyridin-3-yl)methyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[(pyridin-4-yl)methyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[2-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[2-[4-(trifluoromethyl)phenyl]ethyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[3-(trifluoromethyl)anilino][1,4'-bipiperidine]-1'-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[3-(trifluoromethyl)benzoyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[4-(trifluoromethyl)anilino][1,4'-bipiperidine]-1'-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[4-(trifluoromethyl)benzoyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[4-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[6-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[[2-(trifluoromethyl)phenyl]methyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[[3-(trifluoromethyl)phenyl]methyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[[4-(trifluoromethoxy)phenyl]methyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[[4-(trifluoromethyl)phenyl]methyl]-1,4-diazepane-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-4-[[4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-5-[[4-(trifluoromethyl)phenyl]methyl]hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carbothioamide
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-N'-[2-(methyl[[4-(trifluoromethyl)phenyl]methyl]amino)ethyl]thiourea
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)-N'-[2-([[4-(trifluoromethyl)phenyl]methyl]amino)ethyl]thiourea
-
 Homo sapiens
N-(4,6-dimethylpyridin-2-yl)[4-(trifluoromethyl)phenyl]ethanethioamide
-
 Homo sapiens
N-(4-methylpyridin-2-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(4-methylpyridin-2-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carboxamide
-
 Homo sapiens
N-(4-methylpyridin-2-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carboximidamide
-
 Homo sapiens
N-(4-methylquinolin-2-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(pyridin-2-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(pyridin-3-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(pyridin-4-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-(quinolin-2-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-methyl-N-(4-methylpyridin-2-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-[(pyridin-2-yl)methyl]-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
-
 Homo sapiens
N-[1'-[(4,6-dimethylpyridin-2-yl)carbamothioyl][1,4'-bipiperidin]-4-yl]-3-(trifluoromethyl)benzamide
-
 Homo sapiens
N-[1-[(4,6-dimethylpyridin-2-yl)carbamothioyl]piperidin-3-yl]-4-(trifluoromethyl)benzamide
-
 Homo sapiens
[4-[(4,6-dimethylpyridin-2-yl)carbamothioyl]piperazin-1-yl]methyl 2-methoxybenzoate
-
 Homo sapiens
[4-[(4,6-dimethylpyridin-2-yl)carbamothioyl]piperazin-1-yl]methyl 3-methoxybenzoate
-
 Homo sapiens
[4-[(4,6-dimethylpyridin-2-yl)carbamothioyl]piperazin-1-yl]methyl 4-methoxybenzoate
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
 3-phospho-D-glycerate pH 8.0, 22°C Homo sapiens
0.15
-
 NAD+ pH 8.0, 22°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-phospho-D-glycerate + NAD+ Homo sapiens
-
 3-phosphooxypyruvate + NADH + H+
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens O43175
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-phospho-D-glycerate + NAD+
-
 Homo sapiens 3-phosphooxypyruvate + NADH + H+
-
 r

Synonyms

Synonyms Comment Organism
Phgdh
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0025
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[[4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbothioamide
0.0037
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide
0.0043
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[4-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
0.0053
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[[3-(trifluoromethyl)phenyl]methyl]piperazine-1-carbothioamide
0.0057
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-3-[4-(trifluoromethyl)anilino]piperidine-1-carbothioamide
0.0058
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-3-(hydroxymethyl)-4-[[4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbothioamide
0.0063
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
0.0063
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[[2-(trifluoromethyl)phenyl]methyl]piperazine-1-carbothioamide
0.0064
-
 pH 8.0, 22°C Homo sapiens 4-[3-(trifluoromethyl)phenyl]-N-[4-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide
0.0065
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[3-(trifluoromethyl)anilino][1,4'-bipiperidine]-1'-carbothioamide
0.0069
-
 pH 8.0, 22°C Homo sapiens N-(pyridin-2-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
0.0072
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-3-[3-(trifluoromethyl)anilino]piperidine-1-carbothioamide
0.0073
-
 pH 8.0, 22°C Homo sapiens N'-(4,6-dimethylpyridin-2-yl)-N-methyl-N-[2-(methyl[[4-(trifluoromethyl)phenyl]methyl]amino)ethyl]thiourea
0.0073
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[[4-(trifluoromethyl)phenyl]methyl]-1,4-diazepane-1-carbothioamide
0.0077
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[4-(trifluoromethyl)anilino][1,4'-bipiperidine]-1'-carbothioamide
0.008
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[[4-(trifluoromethyl)phenyl]methyl]-1,4-diazepane-1-carbothioamide
0.0083
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-3-methyl-4-[[4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbothioamide
0.0087
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[2-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
0.0087
-
 pH 8.0, 22°C Homo sapiens N-[1-[(4,6-dimethylpyridin-2-yl)carbamothioyl]piperidin-3-yl]-4-(trifluoromethyl)benzamide
0.0089
-
 pH 8.0, 22°C Homo sapiens N-(pyridin-3-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
0.0092
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[(2-methylphenyl)methyl]piperazine-1-carbothioamide
0.0097
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-N'-[2-([[4-(trifluoromethyl)phenyl]methyl]amino)ethyl]thiourea
0.0099
-
 pH 8.0, 22°C Homo sapiens (3S)-N-(4,6-dimethylpyridin-2-yl)-3-methyl-4-[[4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbothioamide
0.01
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)(oxo)[4-(trifluoromethyl)phenyl]ethanethioamide
0.01
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-3-[4-(trifluoromethyl)anilino]piperidine-1-carbothioamide
0.01
-
 pH 8.0, 22°C Homo sapiens N-(quinolin-2-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
0.011
-
 pH 8.0, 22°C Homo sapiens 4-[(3-chlorophenyl)methyl]-N-(4,6-dimethylpyridin-2-yl)piperazine-1-carbothioamide
0.011
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[6-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide
0.011
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[[4-(trifluoromethoxy)phenyl]methyl]piperazine-1-carbothioamide
0.011
-
 pH 8.0, 22°C Homo sapiens N-[1'-[(4,6-dimethylpyridin-2-yl)carbamothioyl][1,4'-bipiperidin]-4-yl]-3-(trifluoromethyl)benzamide
0.012
-
 pH 8.0, 22°C Homo sapiens (3R)-N-(4,6-dimethylpyridin-2-yl)-3-methyl-4-[[4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbothioamide
0.012
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-3-([[4-(trifluoromethyl)phenyl]methyl]amino)piperidine-1-carbothioamide
0.013
-
 pH 8.0, 22°C Homo sapiens methyl 2-([4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioyl]amino)pyridine-4-carboxylate
0.014
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-(3-methoxyphenyl)piperazine-1-carbothioamide
0.014
-
 pH 8.0, 22°C Homo sapiens N-(pyridin-4-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
0.015
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[(4-methylphenyl)methyl]piperazine-1-carbothioamide
0.015
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)[4-(trifluoromethyl)phenyl]ethanethioamide
0.0153
-
 pH 8.0, 22°C Homo sapiens N-(4-methylpyridin-2-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
0.016
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-(4-methoxyphenyl)piperazine-1-carbothioamide
0.016
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-5-[[4-(trifluoromethyl)phenyl]methyl]hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carbothioamide
0.017
-
 pH 8.0, 22°C Homo sapiens 4-[(4-bromophenyl)methyl]-N-(4,6-dimethylpyridin-2-yl)piperazine-1-carbothioamide
0.017
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[(4-methylphenyl)methyl]piperazine-1-carbothioamide
0.019
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[4-(trifluoromethyl)benzoyl]piperazine-1-carbothioamide
0.02
-
 pH 8.0, 22°C Homo sapiens 4-[(2-chlorophenyl)methyl]-N-(4,6-dimethylpyridin-2-yl)piperazine-1-carbothioamide
0.02
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[(3-methylphenyl)methyl]piperazine-1-carbothioamide
0.021
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-N'-[2-(methyl[[4-(trifluoromethyl)phenyl]methyl]amino)ethyl]thiourea
0.021
-
 pH 8.0, 22°C Homo sapiens N-(4-methylquinolin-2-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
0.021
-
 pH 8.0, 22°C Homo sapiens N-[(pyridin-2-yl)methyl]-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
0.022
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[3-(trifluoromethyl)benzoyl]piperazine-1-carbothioamide
0.023
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[2-[4-(trifluoromethyl)phenyl]ethyl]piperazine-1-carbothioamide
0.024
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-(2-methoxyphenyl)piperazine-1-carbothioamide
0.026
-
 pH 8.0, 22°C Homo sapiens [4-[(4,6-dimethylpyridin-2-yl)carbamothioyl]piperazin-1-yl]methyl 4-methoxybenzoate
0.03
-
 pH 8.0, 22°C Homo sapiens [4-[(4,6-dimethylpyridin-2-yl)carbamothioyl]piperazin-1-yl]methyl 3-methoxybenzoate
0.031
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-3-phenyl-4-[[4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbothioamide
0.033
-
 pH 8.0, 22°C Homo sapiens 4-[(4,6-dimethylpyridin-2-yl)carbamothioyl]-1-[[4-(trifluoromethyl)phenyl]methyl]piperazine-2-carboxylic acid
0.037
-
 pH 8.0, 22°C Homo sapiens 4-[3-(trifluoromethyl)phenyl]-N-[4-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide
0.037
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-(pyridin-2-yl)piperazine-1-carbothioamide
0.038
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[(4-fluorophenyl)methyl]piperazine-1-carbothioamide
0.039
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[(3-fluorophenyl)methyl]piperazine-1-carbothioamide
0.04
-
 pH 8.0, 22°C Homo sapiens 4-benzyl-N-(4,6-dimethylpyridin-2-yl)piperazine-1-carbothioamide
0.041
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[(2-fluorophenyl)methyl]piperazine-1-carbothioamide
0.05
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-(pyridin-3-yl)piperazine-1-carbothioamide
0.05
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[(pyridin-2-yl)methyl]piperazine-1-carbothioamide
0.059
-
 pH 8.0, 22°C Homo sapiens N-(4,6-dimethylpyridin-2-yl)-4-[(pyridin-4-yl)methyl]piperazine-1-carbothioamide

General Information

General Information Comment Organism
drug target since the enzyme controls flux through the sreine biosynthetic pathway it represents a putative target in oncology Homo sapiens
metabolism the enzyme catalyzes the first, rate-limiting step in the synthesis of serine from glucose Homo sapiens