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Literature summary for 1.1.1.95 extracted from
- 3-Phosphoglycerate dehydrogenase (3-PGDH) expression is regulated by HOXA10 in murine endometrium and human endometrial cells (2009), Reproduction, 139, 237-245.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | HOAX expression downregulates the enzyme by 40% | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | HOXA10 is required for enzyme regulation in the endometrium | ? | - |
? |  |
| additional information | Homo sapiens | HOXA10 is required for enzyme regulation in the endometrium | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O43175 | - |
- |
| Mus musculus | Q61753 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| endometrium | high expression levels in the proliferative phase | Homo sapiens | - |
| uterine endometrium | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | HOXA10 is required for enzyme regulation in the endometrium | Mus musculus | ? | - |
? | |
| additional information | HOXA10 is required for enzyme regulation in the endometrium | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3-PGDH | - |
Mus musculus |
| 3-PGDH | - |
Homo sapiens |
| 3-phosphoglycerate dehydrogenase | - |
Mus musculus |
| 3-phosphoglycerate dehydrogenase | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | HOXA10 is required for enzyme regulation in the endometrium, HOAX sense expression causes a 2.0fold downregulation of 3-PGDH in endometrial cells | down |
| Homo sapiens | HOXA10 is required for enzyme regulation in the endometrium, HOAX antisense expression, siRNA, causes a 4.4fold upregulation of 3-PGDH in endometrial cells | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme is required for the de novo biosynthesis of L-serine | Mus musculus |
| metabolism | the enzyme is required for the de novo biosynthesis of L-serine | Homo sapiens |
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Release 2023.1 (January 2023)
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